Rational design, synthesis, biologic evaluation, and structure-activity relationship studies of novel 1-indanone alpha(1)-adrenoceptor antagonists.

Rational design, synthesis, biologic evaluation, and structure-activity relationship studies of novel 1-indanone alpha(1)-adrenoceptor antagonists. Research Abstract Details 

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Rational design, synthesis, biologic evaluation, and structure-activity relationship studies of novel 1-indanone alpha(1)-adrenoceptor antagonists. Abstract Text:

Minyong Li,Lin Xia,Minyong Li,Lin Xia,

In the present report, a novel series of 1-indanone alpha(1)-adrenoceptor antagonists were designed and synthesized based on 3D-pharmacophore model. Their in vitro alpha(1)-adrenoceptor antagonistic assay showed that three compounds (2a, 2m, and 2o) had similar or improved alpha(1)-adrenoceptor antagonistic activities relative to the positive control prazosin. Based on these results, a three-dimensional quantitative structure-activity relationship study was performed using a Self-Organizing Molecular Field Analysis method to provide insight for the future development of alpha(1)-adrenoceptor antagonists.

Rational design, synthesis, biologic evaluation, and structure-activity relationship studies of novel 1-indanone alpha(1)-adrenoceptor antagonists. Publishing Authors By Initials

M Li,L Xia,M Li,L Xia,

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Rational design, synthesis, biologic evaluation, and structure-activity relationship studies of novel 1-indanone alpha(1)-adrenoceptor antagonists. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chemical biology & drug design

VOLUME: 70

Page Numbers: 461-4

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ISSN: 1747-0277

DAY: 10

MONTH: 10

YEAR: 2007

Rational design, synthesis, biologic evaluation, and structure-activity relationship studies of novel 1-indanone alpha(1)-adrenoceptor antagonists. Information

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LANGUAGE: eng

NlmUniqueID: 101262549

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Grant and Affiliation Information for Rational design, synthesis, biologic evaluation, and structure-activity relationship studies of novel 1-indanone alpha(1)-adrenoceptor antagonists.

AFFILIATION: Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.

Country: England

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MEDLINETA: Chem Biol Drug Des

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