Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications.

Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications. Research Abstract Details 

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Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications. Abstract Text:

Tina L Amyes,John P Richard,Tina L Amyes,John P Richard,

The structures of the transition states for a variety of enzyme-catalyzed ribosyl group transfer reactions, determined by computational evaluation of multiple tritium and heavy atom kinetic isotope effects on these enzymatic reactions, have been found to show a considerable variation in the extent of bond cleavage at the ribosyl anomeric carbon. The calculated transition-state structures have been used to guide the design of high-affinity transition-state analogue inhibitors for 5'-methylthioadenosine nucleosidases with potential as therapeutic agents.

Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications. Publishing Authors By Initials

TL Amyes,JP Richard,TL Amyes,JP Richard,

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Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications. Journal Published:

PUBLICATION TYPE: Review

Journal: ACS chemical biology

VOLUME: 2

Page Numbers: 711-4

Journal Abbreviation: ACS Chem. Biol.

ISSN: 1554-8937

DAY: 20

MONTH: Nov

YEAR: 2007

Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications. Information

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LANGUAGE: eng

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AFFILIATION: Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260-3000, USA.

Country: United States

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MEDLINETA: ACS Chem Biol

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