Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance.

Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance. Research Abstract Details 

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Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance. Abstract Text:

Wee Han Ang,Isam Khalaila,Claire S Allardyce,Lucienne Juillerat-Jeanneret,Paul J Dyson,

A rationally designed Pt(IV) anticancer compound is described, employing the novel concept of tethering an inhibitor of glutathione-S-transferase, an enzyme associated with Pt-based drug-resistance, to cisplatin. Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described.

Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance. Publishing Authors By Initials

WH Ang,I Khalaila,CS Allardyce,L Juillerat-Jeanneret,PJ Dyson,

For similar organic chemicals: organometallic compounds: organoplatinum compounds research abstracts see: organic chemicals: organometallic compounds: organoplatinum compounds research

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Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 1382-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 9

MONTH: Feb

YEAR: 2005

Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance. Keywords Mesh Terms:

KEYWORDS: Organoplatinum Compounds

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance. Information

Substance Name: Glutathione Transferase

Registry Number: EC 2.5.1.18

Grant and Affiliation Information for Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance.

AFFILIATION: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, EPFL-BCH, CH 1015 Lausanne, Switzerland.

Country: United States

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MEDLINETA: J Am Chem Soc

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