Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis.

Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. Abstract Text:

Gareth M Jenkins,Andrew Rambaut,Oliver G Pybus,Edward C Holmes,

The study of rates of nucleotide substitution in RNA viruses is central to our understanding of their evolution. Herein we report a comprehensive analysis of substitution rates in 50 RNA viruses using a recently developed maximum likelihood phylogenetic method. This analysis revealed a significant relationship between genetic divergence and isolation time for an extensive array of RNA viruses, although more rate variation was usually present among lineages than would be expected under the constraints of a molecular clock. Despite the lack of a molecular clock, the range of statistically significant variation in overall substitution rates was surprisingly narrow for those viruses where a significant relationship between genetic divergence and time was found, as was the case when synonymous sites were considered alone, where the molecular clock was rejected less frequently. An analysis of the ecological and genetic factors that might explain this rate variation revealed some evidence of significantly lower substitution rates in vector-borne viruses, as well as a weak correlation between rate and genome length. Finally, a simulation study revealed that our maximum likelihood estimates of substitution rates are valid, even if the molecular clock is rejected, provided that sufficiently large data sets are analyzed.

Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. Publishing Authors By Initials

GM Jenkins,A Rambaut,OG Pybus,EC Holmes,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of molecular evolution

VOLUME: 54

Page Numbers: 156-65

Journal Abbreviation: J. Mol. Evol.

ISSN: 0022-2844

DAY: 31

MONTH: Feb

YEAR: 2002

Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 360051

Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis.

AFFILIATION: Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Mol Evol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis Related Publications

• Alcohol dehydrogenases: gene multiplicity and differential functions of five classes of isozymes.
• An elastic rod model for anguilliform swimming.
• Assessment of a new Distance Randot stereoacuity test.
• Balancing disfigurement and fear of disease progression: Patient perceptions of HIV body fat redistribution.
• Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome.
• Changes in religiousness and spirituality attributed to HIV/AIDS: are there sex and race differences?
• Correlates of use of different types of complementary and alternative medicine by breast cancer survivors in the nurses' health study.
• Development of Synchrotron Radiation as a High-Intensity Source for X-ray Diffraction.
• Dietary fat and risk of postmenopausal breast cancer in a 20-year follow-up.
• Effect of levetiracetam on visual-spatial memory following status epilepticus.
• Electrical induction of spikes in the hippocampus impairs recognition capacity and spatial memory in rats.
• Emerging sociodemographic and lifestyle predictors of intention to use condom in human immunodeficiency virus intervention among uniformed services personnel.
• Environmental and individual predictors of error in field estimates of blood alcohol concentration: a multilevel analysis.
• Galanin as a modulator of anxiety and depression and a therapeutic target for affective disease.
• Global systems biology and personalized healthcare solutions.
• Human angiotensin-converting enzyme 2 (ACE2) is a receptor for human respiratory coronavirus NL63.
• Human coronavirus 229E can use CD209L (L-SIGN) to enter cells.
• Hydroxyproline ingestion and urinary oxalate and glycolate excretion.
• Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice.
• Molecular interactions of group 1 coronaviruses with feline APN.
• Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range.
• On the dynamics of electrically-coupled neurons with inhibitory synapses.
• Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice.
• Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection.
• Rat coronavirus infection of primary rat alveolar epithelial cells.
• Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis.
• Safety, acceptability, and tolerability of 3 topical microbicides among heterosexual Kenyan men.
• Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus.
• The ABCs of HIV prevention in men: associations with HIV risk and protective behaviors.
• Vulvar intraepithelial neoplasia III in a teenager.