Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA).

Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Research Abstract Details 

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Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Abstract Text:

Melissa D Morgan,Michelle M Mielke,Richard O'Brien,Juan C Troncoso,Alan B Zonderman,Constantine G Lyketsos,Melissa D Morgan,Michelle M Mielke,Richard O'Brien,Juan C Troncoso,Alan B Zonderman,Constantine G Lyketsos,

The prevalence of major depression is increased in Alzheimer disease (AD), but currently the basis of this association remains unclear. The present study examined rates of depression in 4 groups of participants with postmortem examination from the Baltimore Longitudinal Study of Aging: (1) cognitively normal controls with no Alzheimer pathology, (2) cognitively normal individuals with Alzheimer pathology, (3) individuals with mild cognitive impairment plus Alzheimer pathology, (4) individuals with clinical diagnoses of dementia plus Alzheimer pathology. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Individuals with Alzheimer pathology but no cognitive decline before death had significantly lower rates of depression than cognitively normal controls with no Alzheimer pathology and individuals with Alzheimer pathology plus clinical diagnoses of dementia. These findings suggest that depression is a risk factor for AD in the presence of AD pathology, but depression is not a risk factor for AD pathology.

Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Publishing Authors By Initials

MD Morgan,MM Mielke,R O'Brien,JC Troncoso,AB Zonderman,CG Lyketsos,MD Morgan,MM Mielke,R O'Brien,JC Troncoso,AB Zonderman,CG Lyketsos,

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Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Alzheimer disease and associated disorders

VOLUME: 21

Page Numbers: 199-204

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ISSN: 0893-0341

DAY: 6

MONTH: 09

YEAR: 2007

Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Information

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LANGUAGE: eng

NlmUniqueID: 8704771

Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Keywords Mesh Terms:

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Grant and Affiliation Information for Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA).

AFFILIATION: Johns Hopkins University, Baltimore, MD 21224, USA.

Country: United States

AGENCY: United States PHS

GRANT: 5 PO1 AGO5146

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MEDLINETA: Alzheimer Dis Assoc Disord

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