Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies.

Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies. Research Abstract Details 

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Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies. Abstract Text:

Edward Helmes,John V Bowler,Harold Merskey,David G Munoz,Vladimir C I Hachinski,

Increased interest in types of dementia has developed as more cases are identified in aging populations. Here we compare the rates of cognitive decline over time in three groups with dementia from the University of Western Ontario Dementia Study: Alzheimer's disease (AD), dementia with Lewy bodies and a group with both AD and Lewy bodies. All diagnoses were verified by autopsy using standard diagnostic methods. Cognitive impairment was measured with the Extended Scale for Dementia (ESD). Members of each group with dementia were age and sex matched with individuals without dementia as controls. The 15 cases of AD, 7 cases with Lewy bodies and 8 cases with both conditions were all free of significant vascular disease. Linear regression was used to determine the rate of changes in ESD scores over time in months. All three control groups showed no change in cognitive status over time. As expected, all groups with dementia showed progressive cognitive impairment. Analysis of the slope parameter showed that all groups deteriorated at the same rate of approximately 2 ESD points per month. Quadratic models fit better than simple linear models in all groups. Results suggest that the final rate of cognitive decline in dementia may not necessarily reflect the underlying cause.

Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies. Publishing Authors By Initials

E Helmes,JV Bowler,H Merskey,DG Munoz,VC Hachinski,

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Dementia and geriatric cognitive disorders

VOLUME: 15

Page Numbers: 67-71

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 24

MONTH: 03

YEAR: 2003

Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies. Information

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LANGUAGE: eng

NlmUniqueID: 9705200

Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: psychology

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Grant and Affiliation Information for Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies.

AFFILIATION: University of Western Ontario, London, Ont., Canada. Edward.Helmes@jcu.edu.au

Country: Switzerland

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MEDLINETA: Dement Geriatr Cogn Disord

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