Rate code and temporal code for frequency of whisker stimulation in rat primary and secondary somatic sensory cortex.

Rate code and temporal code for frequency of whisker stimulation in rat primary and secondary somatic sensory cortex. Research Abstract Details 

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Rate code and temporal code for frequency of whisker stimulation in rat primary and secondary somatic sensory cortex. Abstract Text:

Peter Melzer,Gregory C Champney,Mark J Maguire,Ford F Ebner,Peter Melzer,Gregory C Champney,Mark J Maguire,Ford F Ebner,

We recorded responses to frequencies of whisker stimulation from 479 neurons in primary (S1) and secondary (S2) somatic sensory cortex of 26 urethane-anesthetized rats. Five whiskers on the right side of the snout were deflected with air puffs at seven frequencies between 1 and 18/s. In left S1 (barrels and septa) and S2, subsets of neurons (5%) responded to whisker stimulation across the entire range of frequencies with > or = 1 electrical discharges/ten stimuli (full responders). In contrast, 60% of the recorded cells responded above threshold only at stimulus frequencies below 6/s and 35% remained subthreshold at all frequencies tested. Thus, the full responders are unique in that they were always responsive and appeared particularly suited to facilitate a dynamic, broadband processing of stimulus frequency. Full responders were most responsive at 1 stimulus/s, and showed greatest synchrony with whisker motion at 18 stimuli/s. The barrel cells responded with the greatest temporal accuracy between 3 and 15 stimuli/s. The septum cells responded less accurately, but maintained their accuracy at all frequencies. Only septum cells continued to increase their discharge rate with increasing stimulus frequency. The S2 cells discharged with lowest temporal accuracy modulated only by stimulus frequencies < or = 6/s and exhibited the steepest decrease in discharge/stimulus with increasing stimulus frequency. Our observations suggest that full responders in the septa are well suited to encode high frequencies of whisker stimulation in timing and rate of discharge. The barrel cells, in contrast, showed the strongest temporal coding at stimulus frequencies in the middle range, and S2 cells were most sensitive to differences in low frequencies. The ubiquitous decline in discharge/stimulus in S1 and S2 may explain the decrease in blood flow observed at increasing stimulus frequency with functional imaging.

Rate code and temporal code for frequency of whisker stimulation in rat primary and secondary somatic sensory cortex. Publishing Authors By Initials

P Melzer,GC Champney,MJ Maguire,FF Ebner,P Melzer,GC Champney,MJ Maguire,FF Ebner,

For similar animal structures: vibrissae research abstracts see: animal structures: vibrissae research

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Rate code and temporal code for frequency of whisker stimulation in rat primary and secondary somatic sensory cortex. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental brain research. Experimentelle Hirnf

VOLUME: 172

Page Numbers: 370-86

Journal Abbreviation:

ISSN: 0014-4819

DAY: 3

MONTH: 02

YEAR: 2006

Rate code and temporal code for frequency of whisker stimulation in rat primary and secondary somatic sensory cortex. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Rate code and temporal code for frequency of whisker stimulation in rat primary and secondary somatic sensory cortex. Keywords Mesh Terms:

KEYWORDS: Vibrissae

MESH TERMS: physiology

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Grant and Affiliation Information for Rate code and temporal code for frequency of whisker stimulation in rat primary and secondary somatic sensory cortex.

AFFILIATION: Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Ave. S, Nashville, TN 37203, USA. peter.melzer@vanderbilt.edu

Country: Germany

AGENCY: United States NINDS

GRANT: NS-25907

ACRONYM: NS

MEDLINETA: Exp Brain Res

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