Rat maternal diabetes impairs pancreatic beta-cell function in the offspring.

Rat maternal diabetes impairs pancreatic beta-cell function in the offspring. Research Abstract Details 

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Rat maternal diabetes impairs pancreatic beta-cell function in the offspring. Abstract Text:

Junying Han,Jianxiang Xu,Yun Shi Long,Paul N Epstein,Ye Q Liu,

It has been shown that maternal diabetes increases the risk for obesity, glucose intolerance, and Type 2 diabetes mellitus in the adult life of the offspring. Mechanisms for these effects on the offspring are not well understood, and little information is available to reveal the mechanisms. We studied the effect of maternal diabetes on beta-cell function in the offspring of streptozotocin (STZ)-induced diabetic rat mothers (STZ-offspring). STZ-offspring did not become glucose intolerant up to 15 wk of age. At this age, however, insulin secretion was significantly impaired, as measured by in vivo and in vitro studies. Consistent with these changes, islet glucose metabolism and some important glucose metabolic enzyme activities were reduced. No significant changes were found in islet morphological analysis. These data indicate that beta-cell function is impaired in adult STZ-offspring; these changes may contribute to the development of type 2 diabetes mellitus in adulthood.

Rat maternal diabetes impairs pancreatic beta-cell function in the offspring. Publishing Authors By Initials

J Han,J Xu,YS Long,PN Epstein,YQ Liu,

For similar pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research abstracts see: pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research

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MEDLINE DATE:

Rat maternal diabetes impairs pancreatic beta-cell function in the offspring. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Endocrinology and

VOLUME: 293

Page Numbers: E228-36

Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

ISSN: 0193-1849

DAY: 27

MONTH: 03

YEAR: 2007

Rat maternal diabetes impairs pancreatic beta-cell function in the offspring. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901226

Rat maternal diabetes impairs pancreatic beta-cell function in the offspring. Keywords Mesh Terms:

KEYWORDS: Weight Gain

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Rat maternal diabetes impairs pancreatic beta-cell function in the offspring. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for Rat maternal diabetes impairs pancreatic beta-cell function in the offspring.

AFFILIATION: Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville College of Medicine, 570 South Preston St., Suite 304, Louisville, KY 40202, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: P20 RR/DE-17702

ACRONYM: DE

MEDLINETA: Am J Physiol Endocrinol Metab

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