[Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction]

[Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction] Research Abstract Details 

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[Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction] Abstract Text:

Y Qian,G Chen,J Huang,

OBJECTIVE: To study immune tolerance induced by blockade of B7-CD28 interaction after heart transplantation in rats. METHODS: A model of rat heterotopic heart allograft was established by using Ono's technique. CTLA-4Ig was administered by intraperitoneal injection at dose of 100 micro. Survival times, histological changes, and the concentration of IL-2, IgG and IgM were measured after operation. RESULTS: Survival times were 31.60 +/- 1.82 days in experimental group and vs 7.25 +/- 0.71 days in control groups. In the experimental group, the graft survival time prolonged significantly (P < 0.01). Histological changes were characterized by mild scattered mononuclear infiltration and patchy myocyte injury in the experimental group (grade I - II). In the control group, the changes were characterized by severe lymphocyte infiltration, myocyte injury and necrosis, interstitial edema, and hemorrhage (grade IV). IL-2 was significantly decreased after operation (P < 0.01). IgG and IgM were not changed significantly in comparison with those in the control group (P > 0.05). CONCLUSION: The blockade B7-CD28 interaction can induce rat heterotopic heart allograft immune tolerance. It may provide a new way to treat immune rejection after transplantation.

[Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction] Publishing Authors By Initials

Y Qian,G Chen,J Huang,

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[Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery

VOLUME: 38

Page Numbers: 306-8, 21

Journal Abbreviation: Zhonghua Wai Ke Za Zhi

ISSN: 0529-5815

DAY: 26

MONTH: Apr

YEAR: 2000

[Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction] Information

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LANGUAGE: chi

NlmUniqueID: 153611

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Grant and Affiliation Information for [Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction]

AFFILIATION: Organ Transplantation Centre, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou, China.

Country: China

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MEDLINETA: Zhonghua Wai Ke Za Zhi

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