Rasmussen's encephalitis: Interleukin-10-dependent Tc2 cell polarization may explain its pathophysiology and clinical course.

Rasmussen's encephalitis: Interleukin-10-dependent Tc2 cell polarization may explain its pathophysiology and clinical course. Research Abstract Details 

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Rasmussen's encephalitis: Interleukin-10-dependent Tc2 cell polarization may explain its pathophysiology and clinical course. Abstract Text:

Ivan Osorio,Alex Shnyra,Karen Santacruz,Ryan Brewington,David Morrison,

Little is known about the cellular immune dynamics and pathophysiology of Rasmussen's encephalitis (RE). We investigated transcriptional expression of pro- and anti-inflammatory cytokines and characterized the T-cell subset types present in temporal and frontal lobe specimens obtained from a child with RE. Interleukin (IL)-10 and macrophage scavenger receptor type I mRNA assessed by semiquantitative reverse transcription polymerase chain reaction was found in temporal but not in affected frontal lobe tissue. Messenger RNA specific to tumor necrosis factor alpha, IL-l, IL-4, IL-6, IL-12, IL-15, IL-18, transforming growth factor beta, CD-14, and inducible nitric oxide synthase was not detected in either temporal or frontal tissue with histopathologically manifest evidence of disease. Virtually all lymphocytic infiltrate consisted of CD3+ CD8+ T cells. We speculate that RE is a disease mediated by Tc2 polarization of the immune response and that its immunohistopathology, natural history, and clinical evolution (chronic, staircase progression) reflect the dual/pleiotropic actions of IL-10, which, depending on the state of activation of the immune system, may be either cytolytic or immunosuppressant.

Rasmussen's encephalitis: Interleukin-10-dependent Tc2 cell polarization may explain its pathophysiology and clinical course. Publishing Authors By Initials

I Osorio,A Shnyra,K Santacruz,R Brewington,D Morrison,

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Rasmussen's encephalitis: Interleukin-10-dependent Tc2 cell polarization may explain its pathophysiology and clinical course. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Epilepsy & behavior : E&B

VOLUME: 10

Page Numbers: 206-11

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ISSN: 1525-5050

DAY: 27

MONTH: 10

YEAR: 2006

Rasmussen's encephalitis: Interleukin-10-dependent Tc2 cell polarization may explain its pathophysiology and clinical course. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Rasmussen's encephalitis: Interleukin-10-dependent Tc2 cell polarization may explain its pathophysiology and clinical course.

AFFILIATION: Department of Neurology and Comprehensive Epilepsy Center, University of Kansas Medical Center, Kansas City, KS, USA.

Country: United States

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MEDLINETA: Epilepsy Behav

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