Rapidly progressive cataract and iris atrophy during treatment of Acanthamoeba keratitis.

Rapidly progressive cataract and iris atrophy during treatment of Acanthamoeba keratitis. Research Abstract Details 

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Rapidly progressive cataract and iris atrophy during treatment of Acanthamoeba keratitis. Abstract Text:

PURPOSE: To identify characteristics associated with cataract occurring during the course of Acanthamoeba keratitis. DESIGN: Retrospective observational case series. PARTICIPANTS: Eighty-one laboratory-confirmed patients with Acanthamoeba keratitis. METHODS: Review of clinical records. MAIN OUTCOME MEASURES: Development of cataract during management of Acanthamoeba keratitis. RESULTS: Rapidly progressive crystalline lens opacification occurred in 9 eyes within 4 to 15 weeks after diagnosis of Acanthamoeba keratitis. Three were associated with inflammatory complications, including anterior scleritis (2 eyes) and iridocyclitis (1 eye). Six others had the abrupt onset of a dense cataract, including 5 with iris atrophy, that occurred during the initial 6 months of therapy with chlorhexidine, a diamidine, and adjunctive corticosteroid. Extracapsular cataract extraction was performed with or after penetrating keratoplasty. Secondary glaucoma developed in 6 of 9 eyes subsequent to iris atrophy (4 eyes) or a cyclitic membrane (2 eyes), and 3 eyes underwent trabeculectomy. CONCLUSIONS: Cataract may occur and progress during the management of Acanthamoeba keratitis in association with anterior segment inflammation, iris atrophy, and secondary glaucoma.

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Rapidly progressive cataract and iris atrophy during treatment of Acanthamoeba keratitis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Ophthalmology

VOLUME: 115

Page Numbers: 866-9

Journal Abbreviation: Ophthalmology

ISSN: 1549-4713

DAY: 2

MONTH: May

YEAR: 2008

Rapidly progressive cataract and iris atrophy during treatment of Acanthamoeba keratitis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Rapidly progressive cataract and iris atrophy during treatment of Acanthamoeba keratitis.

AFFILIATION: Sid W. Richardson Ocular Microbiology Laboratory, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.

Country: United States

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MEDLINETA: Ophthalmology

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