Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters.

Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Research Abstract Details 

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Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Abstract Text:

Emily J Westover,Xiaobo Lin,Terrence E Riehl,Lina Ma,William F Stenson,Douglas F Covey,Richard E Ostlund,

To probe the pathway and specificity of cholesterol absorption, the synthetic enantiomer of cholesterol (ent-cholesterol) and cholesterol were labeled with deuterium, gavaged into hamsters, and measured by negative ion mass spectrometry. Initial uptake of both tracers into the intestinal mucosa at 30 min was similar but cholesterol was temporarily retained there, whereas mucosal ent-cholesterol declined rapidly with concomitantly increased enrichment in both the systemic circulation and the gut lumen. In a 3 day fecal recovery study, ent-cholesterol was quantitatively recovered in the stool, whereas cholesterol absorption was 53.2%. ent-Cholesterol given by intracardiac injection was selectively secreted into bile, and the ratio of ent-cholesterol to cholesterol tracers in the gut lumen increased down the length of the small bowel, with the largest value being found in stool. ent-Cholesterol is efficiently taken up by the intestinal mucosa and undergoes transient enterohepatic recirculation, but it is quantitatively eliminated over 3 days as a result of selective secretion into bile and selective enrichment within the lumen of the intestine. These findings suggest that cholesterol absorption is structurally specific and likely to be mediated by enantiospecific cellular proteins.

Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Publishing Authors By Initials

EJ Westover,X Lin,TE Riehl,L Ma,WF Stenson,DF Covey,RE Ostlund,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of lipid research

VOLUME: 47

Page Numbers: 2374-81

Journal Abbreviation: J. Lipid Res.

ISSN: 0022-2275

DAY: 26

MONTH: 08

YEAR: 2006

Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Information

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LANGUAGE: eng

NlmUniqueID: 376606

Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Information

Substance Name: Cholesterol

Registry Number: 57-88-5

Grant and Affiliation Information for Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters.

AFFILIATION: Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: T32 HL-07275

ACRONYM: HL

MEDLINETA: J Lipid Res

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