Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.

Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Abstract Text:

Theofilos Poutahidis,Kevin M Haigis,Varada P Rao,Prashant R Nambiar,Christie L Taylor,Zhongming Ge,Koichiro Watanabe,Anne Davidson,Bruce H Horwitz,James G Fox,Susan E Erdman,Theofilos Poutahidis,Kevin M Haigis,Varada P Rao,Prashant R Nambiar,Christie L Taylor,Zhongming Ge,Koichiro Watanabe,Anne Davidson,Bruce H Horwitz,James G Fox,Susan E Erdman,

Chronic inflammation of mucosal surfaces renders them increasingly susceptible to epithelial cancers both in humans and mice. We have previously shown that anti-inflammatory CD4(+)CD45RB(lo)CD25(+) regulatory (Treg or T(R)) lymphocytes down-regulate inflammation and block development of bacteria-triggered colitis and colorectal cancer (CRC) in 129/SvEv Rag2-/- mice. Interestingly, T(R) cells collected from Interleukin (IL)-10-deficient cell donors not only failed to suppress carcinogenesis but instead promoted invasive mucinous colonic carcinoma with a strong gender bias expressing in male mice. We found we show that peritoneal invasion in this model is dependent on pleiotropic cytokine IL-6. Mucinous carcinoma arose rapidly and consistently after treatment with IL10-/- T(R) cells, which were found to express Foxp3+ and localize throughout tumor tissue. Carcinogenesis was rapidly reversible with transfer of wild type IL10-competent T(R) cells. Likewise, treatment with IL10-Ig fusion protein was sufficient to revert the lesions histologically, and restore inflammatory cytokine and oncogene expression to base line levels. These studies indicate an essential role for IL 6 in this CRC phenotype. Furthermore, immune-competent T(R) cells were important not only for preventing pathology but also for constructive remodeling of bowel following tumorigenic microbial insults. These data provide insights into etiopathogenesis of inflammation-associated epithelial invasion and maintenance of epithelial homeostasis.

Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Publishing Authors By Initials

T Poutahidis,KM Haigis,VP Rao,PR Nambiar,CL Taylor,Z Ge,K Watanabe,A Davidson,BH Horwitz,JG Fox,SE Erdman,T Poutahidis,KM Haigis,VP Rao,PR Nambiar,CL Taylor,Z Ge,K Watanabe,A Davidson,BH Horwitz,JG Fox,SE Erdman,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Carcinogenesis

VOLUME: 28

Page Numbers: 2614-23

Journal Abbreviation: Carcinogenesis

ISSN: 1460-2180

DAY: 27

MONTH: 08

YEAR: 2007

Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008055

Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.

AFFILIATION: Division of Comparative Medicine.

Country: England

AGENCY: United States NCRR

GRANT: T32RR07036

ACRONYM: RR

MEDLINETA: Carcinogenesis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma Related Publications

• A difficult airway case with GlideScope-assisted fiberoptic intubation.
• Abomasal infusion of butterfat increases milk fat in lactating dairy cows.
• Daily consumption of a dark chocolate containing flavanols and added sterol esters affects cardiovascular risk factors in a normotensive population with elevated cholesterol.
• Dimethylsulfoxide toxicity for seeds. BNWL-480.
• Effects of flour beetles irradiated as pupae. BNWL-480.
• Evaluation of the Dutch version of the migraine quality of life instrument (MSQOL) and its application in headache coping.
• How biological abnormalities separate CFS from depression.
• Human bocavirus in tonsillar lymphocytes.
• Human coronavirus infections in rural Thailand: a comprehensive study using real-time reverse-transcription polymerase chain reaction assays.
• In reply.
• Localization of peripheral pulmonary nodules for thoracoscopic excision: value of CT-guided wire placement.
• Ontogeny and x-radiation sensitivity of the flour beetle, Tribolium. BNWL-480.
• Pediatric adenomatous polyposis syndromes: an update.
• Principal component and multivariate analysis of milk long-chain fatty acid composition during diet-induced milk fat depression.
• Radiation and DDT effects in flour beetles. BNWL-280.
• Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.
• Real-Time Reverse Transcription-PCR Assay for Comprehensive Detection of Human Rhinoviruses.
• STANDARDS FOR THE PREVENTION OF COMPRESSED AIR ILLNESS.
• Screening pneumonia patients for mimivirus.
• Sensitivity of finite helical axis parameters to temporally varying realistic motion utilizing an idealized knee model.
• Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats.
• Staphylococci in cheese: some public health aspects.
• Subdural administration of hydrocortisone in multiple sclerosis: effect of ACTH.
• The effect of nitroglycerin ointment on great saphenous vein targeted venous access site diameter with endovenous laser treatment.
• The quality of microparticulated protein.
• Vitamin A status of alcoholics upon admission and after two weeks of hospitalization.