Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor.

Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Research Abstract Details 

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Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Abstract Text:

S-Y Park,M-Y Jung,H-J Kim,S-J Lee,S-Y Kim,B-H Lee,T-H Kwon,R-W Park,I-S Kim,S-Y Park,M-Y Jung,H-J Kim,S-J Lee,S-Y Kim,B-H Lee,T-H Kwon,R-W Park,I-S Kim,

Rapid phagocytic clearance of apoptotic cells is crucial for the prevention of both inflammation and autoimmune responses. Phosphatidylserine (PS) at the external surface of the plasma membrane has been proposed to function as a general 'eat me' signal for apoptotic cells. Although several soluble bridging molecules have been suggested for the recognition of PS, the PS-specific membrane receptor that binds directly to the exposed PS and provides a tickling signal has yet to be definitively identified. In this study, we provide evidence that stabilin-2 is a novel PS receptor, which performs a key function in the rapid clearance of cell corpses. It recognizes PS on aged red blood cells and apoptotic cells, and mediates their engulfment. The downregulation of stabilin-2 expression in macrophages significantly inhibits phagocytosis, and anti-stabilin-2 monoclonal antibody provokes the release of the anti-inflammatory cytokine, transforming growth factor-beta. Furthermore, the results of time-lapse video analyses indicate that stabilin-2 performs a crucial function in the rapid clearance of aged and apoptotic cells. These data indicate that stabilin-2 is the first of the membrane PS receptors to provide tethering and tickling signals, and may also be involved in the resolution of inflammation and the prevention of autoimmunity.Cell Death and Differentiation (2008) 15, 192-201; doi:10.1038/sj.cdd.4402242; published online 26 October 2007.

Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Publishing Authors By Initials

SY Park,MY Jung,HJ Kim,SJ Lee,SY Kim,BH Lee,TH Kwon,RW Park,IS Kim,SY Park,MY Jung,HJ Kim,SJ Lee,SY Kim,BH Lee,TH Kwon,RW Park,IS Kim,

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Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell death and differentiation

VOLUME: 15

Page Numbers: 192-201

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 26

MONTH: 10

YEAR: 2007

Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Information

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LANGUAGE: eng

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AFFILIATION: [1] 1Department of Biochemistry and Cell Biology, Cell and Matrix ResearchInstitute, School of Medicine, Kyungpook National University, Daegu, Korea [2] 2Department of Biochemistry, School of Medicine, Dongguk University, Kyungju, Korea.

Country: England

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MEDLINETA: Cell Death Differ

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