Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat.

Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat. Research Abstract Details 

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Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat. Abstract Text:

M Weiss,J Pellet,

The firing patterns of single raphe units at the posterior midbrain level were examined in chloralosed rats to assess the effects of cerebellar stimulation and/or harmaline administration. Raphe cells were grouped according to their spontaneous firing rate and other characteristics into two categories. From a total sample of 160 cells, 106 (66%) presenting a slow regular discharge pattern were classified as serotonergic (5-HT cells), whereas 35 (22%), having a faster firing rate, were considered non serotonergic (NS cells). Moreover, 19 (12%) raphe units were non categorized. Cerebellar juxtafastigial (JF) stimulation modified the discharge pattern of 56 (35%) raphe units. The remaining 65% were unaffected by the stimulation. Of the 41 5-HT cells affected by JF stimulation, 28 neurons (68%) showed a systematic increase of their firing rate, whereas of the 12 NS cells affected 8 neurons (66%) were inhibited. It thus appears that cerebellar stimulation has an opposite effect on raphe units according to the cell types. Harmaline administration suppressed the activity of 5-HT cells and increased the discharge rate of NS cells. Moreover, we noticed in the latter units a phase modulation of the firing pattern by pauses occurring with a fixed periodicity of 2.5 to 10 s. Considered in the context of previous studies, these results strongly suggest an inhibitory influence of the raphe system on the olivo-cerebellar circuitry.

Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat. Publishing Authors By Initials

M Weiss,J Pellet,

For similar synaptic transmission research abstracts see: synaptic transmission research

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Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 48

Page Numbers: 163-70

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1982

Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat. Keywords Mesh Terms:

KEYWORDS: Synaptic Transmission

MESH TERMS: drug effects

Chemical & Substance for Abstract: Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat. Information

Substance Name: Serotonin

Registry Number: 50-67-9

Grant and Affiliation Information for Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat.

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Country: GERMANY, WEST

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MEDLINETA: Exp Brain Res

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