Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes.

Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes. Research Abstract Details 

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Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes. Abstract Text:

Simon Gilbody,Peter Bower,Alex J Sutton,

OBJECTIVE: To examine whether randomized economic evaluations report clinical effectiveness estimates that are unrepresentative of the totality of the research literature. STUDY DESIGN AND SETTING: From 36 studies (12,294 patients) of enhanced care for depression, we compared pooled clinical effect sizes in studies with a concurrent economic evaluation to those in studies that did not publish a concurrent economic evaluation, using metaregression. RESULTS: The pooled clinical effect size of studies publishing an economic evaluation was almost twice as large as that of studies that did not publish an economic evaluation (pooled standardized mean difference [SMD] in randomized controlled trials [RCTs] with an economic evaluation=0.34; 95% confidence interval [CI]=0.23-0.46; pooled SMD in RCTs without an economic evaluation=0.17; 95% CI=0.10-0.25). This difference was statistically significant (SMD between group difference=-0.17; 95% CI: -0.31 to -0.02; P=0.02). CONCLUSION: Publication of an economic evaluation of enhanced care for depression was associated with a larger clinical effect size. Cost-effectiveness estimates should be interpreted with caution, and the representativeness of the clinical data on which they are based should always be considered. Further research is needed to explore this observed association and potential bias in other areas.

Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes. Publishing Authors By Initials

S Gilbody,P Bower,AJ Sutton,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes. Journal Published:

PUBLICATION TYPE: Meta-Analysis

Journal: Journal of clinical epidemiology

VOLUME: 60

Page Numbers: 781-6

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ISSN: 0895-4356

DAY: 26

MONTH: 03

YEAR: 2007

Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes. Information

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LANGUAGE: eng

NlmUniqueID: 8801383

Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: economics

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Grant and Affiliation Information for Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes.

AFFILIATION: Department of Health Sciences, University of York, York YO10 5DD, UK. sg519@york.ac.uk

Country: England

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MEDLINETA: J Clin Epidemiol

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