Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site.

Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site. Abstract Text:

Ma Bing,Cheng Da-Sheng,Xia Zhao-Fan,Ben Dao-Feng,Lu Wei,Cao Zhi-Fang,Wang Qiang,He Jia,Chai Jia-Ke,Shen Chuan-An,Sun Yong-Hua,Zhang Guo-An,Hu Xiao-Hua,Bing Ma,Da-Sheng Cheng,Zhao-Fan Xia,Dao-Feng Ben,Wei Lu,Zhi-Fang Cao,Qiang Wang,Jia He,Jia-Ke Chai,Chuan-An Shen,Yong-Hua Sun,Guo-An Zhang,Xiao-Hua Hu,

Wound healing is a dynamic and complex biologic process that could be accelerated by growth factors. To investigate the efficacy of topical recombinant human acidic fibroblast growth factor (rh-aFGF) treatment in deep partial-thickness burn or skin graft donor sites, we designed a randomized, multicenter, double-blind, and placebo-controlled clinical trial. The healing rate, fully healed rate, and healing time were evaluated to assess the efficacy of rh-aFGF application. Laboratory examinations and abnormal signs were used to assess the side and toxic effects. The results showed that the healing rate of burn wounds and skin graft donor sites treated by rh-aFGF was significantly higher than that by placebo, and the mean healed time of burn wounds and skin graft donor sites in the rh-aFGF group was significantly the shorter than that in the placebo group. In conclusion, topical administration of rh-aFGF can accelerate the wound healing process and shorten the healed time. It is a potential therapeutic application for promoting healing of deep partial-thickness burns or skin graft donor sites.

Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site. Publishing Authors By Initials

M Bing,C Da-Sheng,X Zhao-Fan,B Dao-Feng,L Wei,C Zhi-Fang,W Qiang,H Jia,C Jia-Ke,S Chuan-An,S Yong-Hua,Z Guo-An,H Xiao-Hua,B Ma,DS Cheng,ZF Xia,DF Ben,W Lu,ZF Cao,Q Wang,J He,JK Chai,CA Shen,YH Sun,GA Zhang,XH Hu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Wound repair and regeneration : official publicati

VOLUME: 15

Page Numbers: 795-9

Journal Abbreviation:

ISSN: 1067-1927

DAY: 21

MONTH: 11

YEAR: 2007

Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9310939

Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site.

AFFILIATION: Department of Burn Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Wound Repair Regen

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site Related Publications

• Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site.