Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection.

Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection. Abstract Text:

,Thomas Hooton,Noel S Weiss,Robert Gilman,Mark H Wener,Victor Chavez,Rosario Meneses,Juan Echevarria,Margot Vidal,King K Holmes,

BACKGROUND: In children, zinc supplementation reduces the incidence and severity of diarrhea. METHODS: HIV-infected adults with > or =7 days of diarrhea recruited at 3 tertiary hospitals in Lima, Peru, received a zinc sulfate capsule containing 50 mg of elemental zinc twice daily or an identical placebo for 14 days. Outcomes included persistence of diarrhea at day 14 and time until cessation of diarrhea. RESULTS: The 81 subjects randomized to zinc and 78 randomized to placebo were comparable at baseline, except for higher prevalences of certain enteric pathogens in the zinc group; complete follow-up rates were 62% and 69%, respectively. Zinc concentrations were consistent with zinc deficiency at follow-up in 94% of placebo recipients and 66% of zinc recipients (P = 0.01). Persistence of diarrhea at day 14 according to follow-up interview (60% for zinc-treated patients and 57.4% for placebo-treated patients) or to patient diary (42.2% vs. 31.9%) did not differ significantly. Adjusting for enteric pathogens and CD4 count, the hazard ratio (HR) for zinc supplementation and cessation of diarrhea (according to the diaries) was 0.91 (95% confidence interval [CI]: 0.50 to 1.64). CONCLUSION: Supplemental zinc had no significant effect on the duration or remission of diarrhea in HIV-infected adults.

Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection. Publishing Authors By Initials

C ,T Hooton,NS Weiss,R Gilman,MH Wener,V Chavez,R Meneses,J Echevarria,M Vidal,KK Holmes,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of acquired immune deficiency syndromes (1

VOLUME: 43

Page Numbers: 197-201

Journal Abbreviation:

ISSN: 1525-4135

DAY: 1

MONTH: Oct

YEAR: 2006

Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100892005

Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection.

AFFILIATION: Department of Epidemiology, University of Washington, Seattle, WA 98104, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Acquir Immune Defic Syndr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection Related Publications

• Alcohol dehydrogenases: gene multiplicity and differential functions of five classes of isozymes.
• An elastic rod model for anguilliform swimming.
• Assessment of a new Distance Randot stereoacuity test.
• Balancing disfigurement and fear of disease progression: Patient perceptions of HIV body fat redistribution.
• Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome.
• Changes in religiousness and spirituality attributed to HIV/AIDS: are there sex and race differences?
• Correlates of use of different types of complementary and alternative medicine by breast cancer survivors in the nurses' health study.
• Development of Synchrotron Radiation as a High-Intensity Source for X-ray Diffraction.
• Dietary fat and risk of postmenopausal breast cancer in a 20-year follow-up.
• Effect of levetiracetam on visual-spatial memory following status epilepticus.
• Electrical induction of spikes in the hippocampus impairs recognition capacity and spatial memory in rats.
• Emerging sociodemographic and lifestyle predictors of intention to use condom in human immunodeficiency virus intervention among uniformed services personnel.
• Environmental and individual predictors of error in field estimates of blood alcohol concentration: a multilevel analysis.
• Galanin as a modulator of anxiety and depression and a therapeutic target for affective disease.
• Global systems biology and personalized healthcare solutions.
• Human angiotensin-converting enzyme 2 (ACE2) is a receptor for human respiratory coronavirus NL63.
• Human coronavirus 229E can use CD209L (L-SIGN) to enter cells.
• Hydroxyproline ingestion and urinary oxalate and glycolate excretion.
• Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice.
• Molecular interactions of group 1 coronaviruses with feline APN.
• Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range.
• On the dynamics of electrically-coupled neurons with inhibitory synapses.
• Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice.
• Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection.
• Rat coronavirus infection of primary rat alveolar epithelial cells.
• Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis.
• Safety, acceptability, and tolerability of 3 topical microbicides among heterosexual Kenyan men.
• Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus.
• The ABCs of HIV prevention in men: associations with HIV risk and protective behaviors.
• Vulvar intraepithelial neoplasia III in a teenager.