Radioiodination of mouse anti-III beta-tubulin antibodies and their evaluation with respect to their use as diagnostic agents for peripheral neuropathies.

Radioiodination of mouse anti-III beta-tubulin antibodies and their evaluation with respect to their use as diagnostic agents for peripheral neuropathies. Research Abstract Details 

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Radioiodination of mouse anti-III beta-tubulin antibodies and their evaluation with respect to their use as diagnostic agents for peripheral neuropathies. Abstract Text:

Helena ,Veronika ,Daniel Seifert,Hana , ,Karel Kranda,Vlastimil ,Miroslav Fiser,

The monoclonal antibody TU-20 and its scFv fragment were radiolabeled with (125)I in order to develop new imaging agents against the specific neuronal marker III beta-tubulin. The reaction via chloramine-T using thiosulfate as a stopping reductant was determined as the most convenient way for radioiodination. The preserved immunological properties of radioiodinated species were estimated by ELISA, electrophoresis, and immunohistochemistry with autoradiography. Biodistribution studies revealed a different behavior of radioiodinated TU-20 and its scFv.

Radioiodination of mouse anti-III beta-tubulin antibodies and their evaluation with respect to their use as diagnostic agents for peripheral neuropathies. Publishing Authors By Initials

H ,V ,D Seifert,H ,J ,K Kranda,V ,M Fiser,

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Radioiodination of mouse anti-III beta-tubulin antibodies and their evaluation with respect to their use as diagnostic agents for peripheral neuropathies. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Applied radiation and isotopes : including data, i

VOLUME: 66

Page Numbers: 310-6

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ISSN: 0969-8043

DAY: 19

MONTH: 09

YEAR: 2007

Radioiodination of mouse anti-III beta-tubulin antibodies and their evaluation with respect to their use as diagnostic agents for peripheral neuropathies. Information

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LANGUAGE: eng

NlmUniqueID: 9306253

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Grant and Affiliation Information for Radioiodination of mouse anti-III beta-tubulin antibodies and their evaluation with respect to their use as diagnostic agents for peripheral neuropathies.

AFFILIATION: Nuclear Physics Institute of the ASCR, v.v.i., CZ-250 68 Rez near Prague, Czech Republic; Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, Brehová 7, CZ-115 19 Prague 1, Czech Republic.

Country: England

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MEDLINETA: Appl Radiat Isot

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