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Radiation-induced brain tumours after central nervous system irradiation in childhood: a review.

Radiation-induced brain tumours after central nervous system irradiation in childhood: a review. Research Abstract Details 

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  • Radiation-induced brain tumours after central nervous system irradiation in childhood: a review. Abstract Text:

    OBJECTS: Radiation-induced cerebral tumours constitute a significant risk for subjects undergoing radiotherapy for the management of cerebral neoplasms. Age-related cerebral vulnerability could be a specific factor in the genesis of these complications. METHODS: The pertinent literature of both paediatric and adult series has been reviewed. Three personal cases were added. RESULTS: One hundred forty-two paediatric second brain tumours were evaluated. Out of them, 69 were malignant gliomas, 33 meningiomas, 8 sarcomatous lesions and 13 low-grade astrocytomas. The average latency period for the appearance of the second tumour was 8 years. Among the second tumours occurring in adults, meningioma is the most common. In this subgroup, the latency period ranged between 16 and 30 years. CONCLUSION: Paediatric radiation-induced brain tumours differ from the adult counterpart for both the histological subtypes. These figures indicate a specific vulnerability of the infantile brain demonstrated by the most frequent occurrence of highly malignant lesions.

    Radiation-induced brain tumours after central nervous system irradiation in childhood: a review. Publishing Authors By Initials

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    PUBMED ID PMID:

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    Radiation-induced brain tumours after central nervous system irradiation in childhood: a review. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Child's nervous system : ChNS : official journal o

    VOLUME: 24

    Page Numbers: 793-805

    Journal Abbreviation:

    ISSN: 0256-7040

    DAY: 8

    MONTH: 04

    YEAR: 2008

    Radiation-induced brain tumours after central nervous system irradiation in childhood: a review. Information

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    LANGUAGE: eng

    NlmUniqueID: 8503227

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    Grant and Affiliation Information for Radiation-induced brain tumours after central nervous system irradiation in childhood: a review.

    AFFILIATION: Institute of Neurosurgery, Division of Paediatric Neurosurgery, Catholic University of Rome, Largo Agostino Gemelli, 8, 00168, Rome, Italy, benedettaludovica@virgilio.it.

    Country: Germany

    Germany Research PublicationGermany Research Publication

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    MEDLINETA: Childs Nerv Syst

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