Radial glial cell heterogeneity--the source of diverse progeny in the CNS.

Radial glial cell heterogeneity--the source of diverse progeny in the CNS. Research Abstract Details 

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Radial glial cell heterogeneity--the source of diverse progeny in the CNS. Abstract Text:

Luisa Pinto,Magdalena ,

Here, we discuss the identity, heterogeneity and functions of radial glial cells mostly in the developing central nervous system (CNS). First, we define radial glial cells by morphological, cell biological and molecular criteria as true glial cells, akin to astroglia. We then describe the appearance of radial glial cells during neural development as a precursor intermediate between immature neuroepithelial cells and differentiating progeny. Then we review the diverse progeny arising in different lineages from radial glial cells as observed by clonal analyses and time-lapse imaging. This leads us to discuss the molecular mechanisms involved in the regulation of the lineage heterogeneity of radial glial cells - including their diversity in distinct regions of the CNS. We conclude by considering the possible mechanisms allowing neurogenic radial glial cells to persist into adulthood in various vertebrate classes ranging from fish to birds, while neurogenic glial cells become restricted to few small regions of the adult forebrain in mice and men.

Radial glial cell heterogeneity--the source of diverse progeny in the CNS. Publishing Authors By Initials

L Pinto,M ,

For similar nervous system: neuroglia research abstracts see: nervous system: neuroglia research

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Radial glial cell heterogeneity--the source of diverse progeny in the CNS. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in neurobiology

VOLUME: 83

Page Numbers: 2-23

Journal Abbreviation: Prog. Neurobiol.

ISSN: 0301-0082

DAY: 7

MONTH: 03

YEAR: 2007

Radial glial cell heterogeneity--the source of diverse progeny in the CNS. Information

Number of References: 248

LANGUAGE: eng

NlmUniqueID: 370121

Radial glial cell heterogeneity--the source of diverse progeny in the CNS. Keywords Mesh Terms:

KEYWORDS: Neuroglia

MESH TERMS: cytology

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Grant and Affiliation Information for Radial glial cell heterogeneity--the source of diverse progeny in the CNS.

AFFILIATION: Institute of Stem Cell Research, GSF-National Research Center for Health and Environment, Ingolstädter Landstr. 1, D-85764 Neuherberg/München, Germany.

Country: England

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MEDLINETA: Prog Neurobiol

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