Rad52 and Rad59 exhibit both overlapping and distinct functions.

Rad52 and Rad59 exhibit both overlapping and distinct functions. Research Abstract Details 

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Rad52 and Rad59 exhibit both overlapping and distinct functions. Abstract Text:

Qi Feng,Louis , de Mayolo, Lettier,Michael Lisby,Naz Erdeniz,Uffe H Mortensen,Rodney Rothstein,

Homologous recombination is an important pathway for the repair of DNA double-strand breaks (DSBs). In the yeast Saccharomyces cerevisiae, Rad52 is a central recombination protein, whereas its paralogue, Rad59, plays a more subtle role in homologous recombination. Both proteins can mediate annealing of complementary single-stranded DNA in vitro, but only Rad52 interacts with replication protein A and the Rad51 recombinase. We have studied the functional overlap between Rad52 and Rad59 in living cells using chimeras of the two proteins and site-directed mutagenesis. We find that Rad52 and Rad59 have both overlapping as well as separate functions in DSB repair. Importantly, the N-terminus of Rad52 possesses functions not supplied by Rad59, which may account for its central role in homologous recombination.

Rad52 and Rad59 exhibit both overlapping and distinct functions. Publishing Authors By Initials

Q Feng,L ,AA de Mayolo,G Lettier,M Lisby,N Erdeniz,UH Mortensen,R Rothstein,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research

PUBMED ID PMID:

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Rad52 and Rad59 exhibit both overlapping and distinct functions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: DNA repair

VOLUME: 6

Page Numbers: 27-37

Journal Abbreviation: DNA Repair (Amst.)

ISSN: 1568-7864

DAY: 20

MONTH: 09

YEAR: 2006

Rad52 and Rad59 exhibit both overlapping and distinct functions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101139138

Rad52 and Rad59 exhibit both overlapping and distinct functions. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: metabolism

Chemical & Substance for Abstract: Rad52 and Rad59 exhibit both overlapping and distinct functions. Information

Substance Name: Rad51 Recombinase

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for Rad52 and Rad59 exhibit both overlapping and distinct functions.

AFFILIATION: Department of Genetics & Development, Columbia University Medical Center, 701 West 168th Street, New York, NY 10032-2704, USA.

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM50237

ACRONYM: GM

MEDLINETA: DNA Repair (Amst)

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