RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia.

RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Research Abstract Details 

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RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Abstract Text:

Sara Rollinson,Alexandra G Smith,James M Allan,Peter J Adamson,Kathryn Scott,Christine F Skibola,Martyn T Smith,Gareth J Morgan,

Homologous recombination (HR) is one of the main pathways for the repair of DNA double strand breaks (DSBs). To investigate whether inherited variants in genes encoding proteins that repair DSBs by HR modulate acute myeloid leukaemia (AML) risk, we have examined the frequency of two variants in the 5' untranslated region (UTR) of RAD51 (RAD51 135 G>C and the RAD51 172 G>T) in a large case-control study of acute myeloid leukaemia (AML). Inheritance of a RAD51 135 C allele was associated with a reduced risk of estimate for AML (odds ratio (OR) 0.56, 95% confidence intervals (CI), 0.38-0.83), while the RAD51 172 T allele was not associated with AML. The RAD51 135 and 172 variants were in strong linkage disequilibrium, with three out of the four possible haplotypes being observed in the population. The protective effect associated with the RAD51 135 C allele was found to be associated with inheritance of the RAD51 135-172 C-G haplotype (cases 3.9% versus controls 6.5%, OR 0.61, 95% CI 0.42-0.90). These data suggest that variants in the RAD51 HR gene may modulate genetic predisposition to AML.

RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Publishing Authors By Initials

S Rollinson,AG Smith,JM Allan,PJ Adamson,K Scott,CF Skibola,MT Smith,GJ Morgan,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Leukemia research

VOLUME: 31

Page Numbers: 169-74

Journal Abbreviation: Leuk. Res.

ISSN: 0145-2126

DAY: 4

MONTH: 08

YEAR: 2006

RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7706787

RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Information

Substance Name: Rad51 Recombinase

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia.

AFFILIATION: Division of Laboratory and Regenerative Medicine, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom. Sara.Rollinson@manchester.ac.uk

Country: England

AGENCY: United States NIEHS

GRANT: P30 ES01896

ACRONYM: ES

MEDLINETA: Leuk Res

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