Racial differences of lipoprotein subclass distributions in postmenopausal women.

Racial differences of lipoprotein subclass distributions in postmenopausal women. Research Abstract Details 

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Racial differences of lipoprotein subclass distributions in postmenopausal women. Abstract Text:

BACKGROUND: We assessed racial differences in lipoprotein particle size, a marker of atherosclerosis risk, among women with coronary disease. METHODS: We studied 378 women (33% non-White, predominantly African American) at the baseline visit of the Women's Angiographic Vitamin and Estrogen Trial (WAVE), a multicenter trial of hormone replacement and antioxidant vitamin therapy in postmenopausal women with established coronary artery disease. Average particle sizes for high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein were measured by nuclear magnetic resonance in these women, and angiography was performed at baseline and followup. RESULTS: Adjusted for age, race, diabetes, smoking, blood pressure, and use of lipid-lowering and antihypertensive medications, non-White women had larger LDL particle size (difference .2 nm, 95% CI .1-.3 nm) and HDL particle size (difference.2 nm, 95% CI .1-.2 nm). Neither angiographic disease progression nor survival without myocardial infarction (median follow-up time of 2.8 years) was associated with lipoprotein particle size or race. CONCLUSIONS: Non-White women have a less atherogenic profile of lipoprotein particle sizes than do White women. However, this difference did not affect event-free survival or angiographic progression of coronary atherosclerosis.

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Racial differences of lipoprotein subclass distributions in postmenopausal women. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Ethnicity & disease

VOLUME: 18

Page Numbers: 176-80

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ISSN: 1049-510X

DAY: 29

MONTH: 05

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 9109034

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AFFILIATION: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Country: United States

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MEDLINETA: Ethn Dis

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