Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis.

Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis. Research Abstract Details 

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Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis. Abstract Text:

Anastassia V Komarova, Real,Andrew M Borman, Brocard,Patrick England, Tordo,John W B Hershey,Katherine M Kean,Yves Jacob,

Viral proteins are frequently multifunctional to accommodate the high density of information encoded in viral genomes. Matrix (M) protein of negative-stranded RNA viruses such as Rhabdoviridae is one such example. Its primary function is virus assembly/budding but it is also involved in the switch from viral transcription to replication and the concomitant down regulation of host gene expression. In this study we undertook a search for potential rabies virus (RV) M protein's cellular partners. In a yeast two-hybrid screen the eIF3h subunit was identified as an M-interacting cellular factor, and the interaction was validated by co-immunoprecipitation and surface plasmon resonance assays. Upon expression in mammalian cell cultures, RV M protein was localized in early small ribosomal subunit fractions. Further, M protein added in trans inhibited in vitro translation on mRNA encompassing classical (Kozak-like) 5'-UTRs. Interestingly, translation of hepatitis C virus IRES-containing mRNA, which recruits eIF3 via a different noncanonical mechanism, was unaffected. Together, the data suggest that, as a complement to its functions in virus assembly/budding and regulation of viral transcription, RV M protein plays a role in inhibiting translation in virus-infected cells through a protein-protein interaction with the cellular translation machinery.

Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis. Publishing Authors By Initials

AV Komarova,E Real,AM Borman,M Brocard,P England,N Tordo,JW Hershey,KM Kean,Y Jacob,

For similar proteins: viral proteins: viral structural proteins: viral envelope proteins: viral matrix proteins research abstracts see: proteins: viral proteins: viral structural proteins: viral envelope proteins: viral matrix proteins research

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Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nucleic acids research

VOLUME: 35

Page Numbers: 1522-32

Journal Abbreviation:

ISSN: 1362-4962

DAY: 7

MONTH: 02

YEAR: 2007

Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis. Information

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LANGUAGE: eng

NlmUniqueID: 411011

Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis. Keywords Mesh Terms:

KEYWORDS: Viral Matrix Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis. Information

Substance Name: Viral Matrix Proteins

Registry Number: 0

Grant and Affiliation Information for Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis.

AFFILIATION: Unité de la Régulation de la Traduction Eucaryote et Virale, CNRS URA 1966, Unité de Génétique Papillomavirus et Cancer Humain, Plate-forme de Biophysique des Macromolecules et de leurs interactions, Institute Pasteur, 75015 Paris, France.

Country: England

AGENCY: United States NIGMS

GRANT: GM22135

ACRONYM: GM

MEDLINETA: Nucleic Acids Res

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