Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Research Abstract Details 

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Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Abstract Text:

Patrick T Caswell,Heather J Spence,Maddy Parsons,Dominic P White,Katherine Clark,Kwai Wa Cheng,Gordon B Mills,Martin J Humphries,Anthea J Messent,Kurt I Anderson,Mary W McCaffrey,Bradford W Ozanne,Jim C Norman,Patrick T Caswell,Heather J Spence,Maddy Parsons,Dominic P White,Katherine Clark,Kwai Wa Cheng,Gordon B Mills,Martin J Humphries,Anthea J Messent,Kurt I Anderson,Mary W McCaffrey,Bradford W Ozanne,Jim C Norman,Patrick T Caswell,Heather J Spence,Maddy Parsons,Dominic P White,Katherine Clark,Kwai Wa Cheng,Gordon B Mills,Martin J Humphries,Anthea J Messent,Kurt I Anderson,Mary W McCaffrey,Bradford W Ozanne,Jim C Norman,

Here, we report a direct interaction between the beta1 integrin cytoplasmic tail and Rab25, a GTPase that has been linked to tumor aggressiveness and metastasis. Rab25 promotes a mode of migration on 3D matrices that is characterized by the extension of long pseudopodia, and the association of the GTPase with alpha5beta1 promotes localization of vesicles that deliver integrin to the plasma membrane at pseudopodial tips as well as the retention of a pool of cycling alpha5beta1 at the cell front. Furthermore, Rab25-driven tumor-cell invasion into a 3D extracellular matrix environment is strongly dependent on ligation of fibronectin by alpha5beta1 integrin and the capacity of Rab25 to interact with beta1 integrin. These data indicate that Rab25 contributes to tumor progression by directing the localization of integrin-recycling vesicles and thereby enhancing the ability of tumor cells to invade the extracellular matrix.

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Publishing Authors By Initials

PT Caswell,HJ Spence,M Parsons,DP White,K Clark,KW Cheng,GB Mills,MJ Humphries,AJ Messent,KI Anderson,MW McCaffrey,BW Ozanne,JC Norman,PT Caswell,HJ Spence,M Parsons,DP White,K Clark,KW Cheng,GB Mills,MJ Humphries,AJ Messent,KI Anderson,MW McCaffrey,BW Ozanne,JC Norman,PT Caswell,HJ Spence,M Parsons,DP White,K Clark,KW Cheng,GB Mills,MJ Humphries,AJ Messent,KI Anderson,MW McCaffrey,BW Ozanne,JC Norman,

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Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental cell

VOLUME: 13

Page Numbers: 496-510

Journal Abbreviation: Dev. Cell

ISSN: 1534-5807

DAY: 10

MONTH: Oct

YEAR: 2007

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Information

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LANGUAGE: eng

NlmUniqueID: 101120028

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Grant and Affiliation Information for Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.

AFFILIATION: Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

Country: United States

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MEDLINETA: Dev Cell

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