Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary.

Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary. Research Abstract Details 

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Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary. Abstract Text:

Nicholas Bogard,Lan Lan,Jiang Xu,Robert S Cohen,Nicholas Bogard,Lan Lan,Jiang Xu,Robert S Cohen,

All stem cells have the ability to balance their production of self-renewing and differentiating daughter cells. The germline stem cells (GSCs) of the Drosophila ovary maintain such balance through physical attachment to anterior niche cap cells and stereotypic cell division, whereby only one daughter remains attached to the niche. GSCs are attached to cap cells via adherens junctions, which also appear to orient GSC division through capture of the fusome, a germline-specific organizer of mitotic spindles. Here we show that the Rab11 GTPase is required in the ovary to maintain GSC-cap cell junctions and to anchor the fusome to the anterior cortex of the GSC. Thus, rab11-null GSCs detach from niche cap cells, contain displaced fusomes and undergo abnormal cell division, leading to an early arrest of GSC differentiation. Such defects are likely to reflect a role for Rab11 in E-cadherin trafficking as E-cadherin accumulates in Rab11-positive recycling endosomes (REs) and E-cadherin and Armadillo (beta-catenin) are both found in reduced amounts on the surface of rab11-null GSCs. The Rab11-positive REs through which E-cadherin transits are tightly associated with the fusome. We propose that this association polarizes the trafficking by Rab11 of E-cadherin and other cargoes toward the anterior cortex of the GSC, thus simultaneously fortifying GSC-niche junctions, fusome localization and asymmetric cell division. These studies bring into focus the important role of membrane trafficking in stem cell biology.

Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary. Publishing Authors By Initials

N Bogard,L Lan,J Xu,RS Cohen,N Bogard,L Lan,J Xu,RS Cohen,

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Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Development (Cambridge, England)

VOLUME: 134

Page Numbers: 3413-8

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 22

MONTH: 08

YEAR: 2007

Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary.

AFFILIATION: University of Kansas, Department of Molecular Biosciences, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.

Country: England

AGENCY: United States NIGMS

GRANT: R01 GM068022-01

ACRONYM: GM

MEDLINETA: Development

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