"Genes".

"Genes". Research Abstract Details 

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"Genes". Abstract Text:

In order to describe a cell at molecular level, a notion of a "gene" is neither necessary nor helpful. It is sufficient to consider the molecules (i.e., chromosomes, transcripts, proteins) and their interactions to describe cellular processes. The downside of the resulting high resolution is that it becomes very tedious to address features on the organismal and phenotypic levels with a language based on molecular terms. Looking for the missing link between biological disciplines dealing with different levels of biological organization, we suggest to return to the original intent behind the term "gene". To this end, we propose to investigate whether a useful notion of "gene" can be constructed based on an underlying notion of function, and whether this can serve as the necessary link and embed the various distinct gene concepts of biological (sub)disciplines in a coherent theoretical framework. In reply to the Genon Theory recently put forward by Klaus Scherrer and Jürgen Jost in this journal, we shall discuss a general approach to assess a gene definition that should then be tested for its expressiveness and potential cross-disciplinary relevance.

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"Genes". Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Theory in biosciences = Theorie in den Biowissensc

VOLUME: 127

Page Numbers: 215-21

Journal Abbreviation: Theory Biosci.

ISSN: 1611-7530

DAY: 5

MONTH: 03

YEAR: 2008

"Genes". Information

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LANGUAGE: eng

NlmUniqueID: 9708216

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Grant and Affiliation Information for "Genes".

AFFILIATION: Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, NM, 87501, USA. sonja@santafe.edu

Country: Germany

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MEDLINETA: Theory Biosci

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