"Everybody in the world is my friend" hypersociability in young children with Williams syndrome.

"Everybody in the world is my friend" hypersociability in young children with Williams syndrome. Research Abstract Details 

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"Everybody in the world is my friend" hypersociability in young children with Williams syndrome. Abstract Text:

Williams syndrome (WS) is a rare genetic disorder involving a characteristic cardiac defect, typical facial appearance, and an uneven profile of cognitive strengths and weaknesses. WS is caused by a hemizygous deletion in chromosome band 7q11.23, including the gene for elastin (ELN). Typically, individuals with WS seem driven to greet and interact with strangers. The goal of the present study was to investigate age-related changes in the expression of hypersociability in WS. Parents of 64 children with WS, 31 children with Down syndrome (DS), and 27 normal controls (NC) provided data concerning specific aspects of their children's social behavior using the Salk Institute Sociability Questionnaire (SISQ). Children ranged in age from 1 year, 1 month to 12 years, 10 months. Consistent with earlier findings, whole group analyses showed the WS group to be significantly higher on all aspects of sociability studied. Comparisons among the groups at different ages revealed that hypersociability is evident even among very young children with WS, and, significantly, children with WS exceed children with DS with respect to Global Sociability and Approach Strangers in every age group. The findings from children who have the typical deletion for WS are contrasted with data obtained from a young child with WS who has a smaller deletion and many physical features of WS, but who does not demonstrate hypersociability, providing intriguing clues to a genetic basis of social behavior in this syndrome. These data suggest the involvement of a genetic predisposition in the expression of hypersociability in WS.

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"Everybody in the world is my friend" hypersociability in young children with Williams syndrome. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of medical genetics. Part A

VOLUME: 124A

Page Numbers: 263-73

Journal Abbreviation: Am. J. Med. Genet. A

ISSN: 1552-4825

DAY: 30

MONTH: Jan

YEAR: 2004

"Everybody in the world is my friend" hypersociability in young children with Williams syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 101235741

"Everybody in the world is my friend" hypersociability in young children with Williams syndrome. Keywords Mesh Terms:

KEYWORDS: Williams Syndrome

MESH TERMS: psychology

Chemical & Substance for Abstract: "Everybody in the world is my friend" hypersociability in young children with Williams syndrome. Information

Substance Name: Elastin

Registry Number: 9007-58-3

Grant and Affiliation Information for "Everybody in the world is my friend" hypersociability in young children with Williams syndrome.

AFFILIATION: Laboratory for Cognitive Neuroscience, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. doyle@salk.edu

Country: United States

AGENCY: United States NINDS

GRANT: P50 NS22343

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MEDLINETA: Am J Med Genet A

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