"Click" synthesis of small-molecule inhibitors targeting caspases.

"Click" synthesis of small-molecule inhibitors targeting caspases. Research Abstract Details 

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"Click" synthesis of small-molecule inhibitors targeting caspases. Abstract Text:

Su Ling Ng,Peng-Yu Yang,Kitty Y-T Chen,Rajavel Srinivasan,Shao Q Yao,Su Ling Ng,Peng-Yu Yang,Kitty Y-T Chen,Rajavel Srinivasan,Shao Q Yao,

A panel of 198 P(4)-diversified aldehyde (reversible) and vinyl sulfone (irreversible) inhibitors is successfully synthesized via an efficient "click chemistry" platform and directly screened against caspase-3 and -7 for inhibition.

"Click" synthesis of small-molecule inhibitors targeting caspases. Publishing Authors By Initials

SL Ng,PY Yang,KY Chen,R Srinivasan,SQ Yao,SL Ng,PY Yang,KY Chen,R Srinivasan,SQ Yao,

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"Click" synthesis of small-molecule inhibitors targeting caspases. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic & biomolecular chemistry

VOLUME: 6

Page Numbers: 844-7

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 4

MONTH: 02

YEAR: 2008

"Click" synthesis of small-molecule inhibitors targeting caspases. Information

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LANGUAGE: eng

NlmUniqueID: 101154995

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Grant and Affiliation Information for "Click" synthesis of small-molecule inhibitors targeting caspases.

AFFILIATION: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore117543. chmyaosq@nus.edu.sg.

Country: England

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MEDLINETA: Org Biomol Chem

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