"Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition.

"Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

"Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition. Abstract Text:

Hybrid glycopeptide beta-lactam mimetics designed to bind lectins or carbohydrate recognition domains in selectins have been prepared according to a "shape-modulating linker" design. This approach was implemented using the azide-alkyne "click" cycloaddition reaction, and as shown by NMR/MD experiments, binding of the resulting mimetics to Ulex Europaeus Lectin-1 (UEL-1) occurred after a "bent-to-extended" conformational change around a partially rotatable triazolylmethylene moiety.

"Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

"Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic letters

VOLUME: 10

Page Numbers: 2227-30

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 9

MONTH: 05

YEAR: 2008

"Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890393

"Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: "Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for "Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition.

AFFILIATION:

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Org Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

"Click" Saccharide/beta-Lactam Hybrids for Lectin Inhibition Related Publications

• Activation of ERK1/2 and TNF-alpha production are mediated by calcium/calmodulin, and PKA signaling pathways during Mycobacterium bovis infection.
• Blocking EphA4 upregulation after spinal cord injury results in enhanced chronic pain.
• Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium.
• Cord blood inflammatory markers, foetal vasculitis and cerebral MRI abnormalities in preterm infants.
• Crossover site-selectivity in the adsorption of the fullerene derivative PCBM on Au(111).
• Does stigma keep poor young immigrant and u.s.-Born black and latina women from seeking mental health care?
• Efficient oxidative radical spirolactamization.
• Electric field distribution and energy absorption in anisotropic and dispersive red blood cells.
• Embryonic cerebral cortical progenitors are resistant to apoptosis, but increase expression of suicide receptor DISC-complex genes and suppress autophagy following ethanol exposure.
• EphB3 receptor and ligand expression in the adult rat brain.
• Ethanol regulates angiogenic cytokines during neural development: evidence from an in vitro model of mitogen-withdrawal-induced cerebral cortical neuroepithelial differentiation.
• Incorporating a built environment module into an accelerated second-degree community health nursing course.
• Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery.
• Instrumental learning within the spinal cord: underlying mechanisms and implications for recovery after injury.
• Leishmania amazonensis infections in Oryzomys acritus and Oryzomys nitidus from Bolivia.
• Locking plate technology and its role in osteoporotic fractures.
• Measuring trends in mental health care disparities, 2000 2004.
• Mycobacterium bovis BCG Toll-Like Receptors 2 and 4 Cooperation Increases the Innate Epithelial Immune Response.
• Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor.
• Prevalence and risk factors for chronic hepatitis B in HIV patients attended at a sexually-transmitted disease clinic in Vitoria, Brazil.
• Reducing the burden of depression: building villages for coordinated care.
• Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response.
• Scintigraphic validation of AC Biosusceptometry to study the gastric motor activity and the intragastric distribution of food in humans.
• The activation function of TMS on a finite element model of a cortical sulcus.
• [Challenges for our century: an environmentally healthy world is possible.]
• [Merkel cell carcinoma: a report of two cases]
• [Neuroimaging in preterm infants.]
• [Plasma concentrations of beta-endorphins in the children of alcoholic patients]
• [Soleus veins: anatomic basis and their role in the origin of deep venous lower limb thrombosis]
• [Stage IIIA and IIIB non-small cell lung cancer: results of chemotherapy combined with radiation therapy and analysis of prognostic factors]