"Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw.

"Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

"Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. Abstract Text:

INTRODUCTION: Bisphosphonates (BPs) have transformed our ability to treat certain malignancies, osteoporosis and hypercalcaemia. This class of drug is assumed to be well tolerated by most. There are some important caveats to this assumption, however, one of the significances being the risk of osteonecrosis of the jaw (ONJ). MATERIAL AND METHODS: This multi-centre retrospective study examined the role of different BPs on the development of ONJ, its clinical presentation and the efficacy of various treatment modalities, comparing these findings with the available literature. RESULTS: A total of 78 patients from 17 centres were identified with ONJ. A majority of patients identified with ONJ had used Pamidronate or Zoledronate (93.6%) intravenously. 94.9% of patients had received BP in the course of treatment for malignancies and a majority had also received prior chemotherapy or exogenous steroids. 82.1% of patients had received BP for more than 1 year. The mean time from the introduction of BP to the development of ONJ in 24 patients from our department was 31.8 months. CONCLUSIONS: The most common intraoral manifestation was exposed necrotic jawbone. Tooth extractions and oral surgical intervention appear to place patients on BP therapy at risk of ONJ, especially after intravenous BP treatments. ONJ proved in this study to be remarkably refractory to treatment, with radical resection being the only curative approach. We recommend that all patients receive necessary dental treatment prior to commencing BP therapy.

"Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

"Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cranio-maxillo-facial surgery : officia

VOLUME: 36

Page Numbers: 95-103

Journal Abbreviation:

ISSN: 1010-5182

DAY: 30

MONTH: 01

YEAR: 2008

"Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8704309

"Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: "Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for "Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw.

AFFILIATION: Department of Oral and Maxillofacial Surgery and Plastic Surgery (Head: Prof. Dr. Dr. Thomas Kreusch), Asklepios Klinik Nord, Hamburg, Germany.

Country: Scotland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Craniomaxillofac Surg

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

"Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw Related Publications

• "Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw.
• Crystal structure of human Pus10, a novel pseudouridine synthase.
• [Long-term results of fittig subperiosteal implants: report of twelve patient cases]
• [Secondary reconstruction of the mandible with a 2,7-mm-bridging-plate]