"AKT"ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation.

"AKT"ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation. Research Abstract Details 

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"AKT"ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation. Abstract Text:

Mark Sussman,Mark Sussman,

Cardiac development and postnatal growth depend on activation of AKT, but initial strategies to improve myocardial repair using AKT were stymied by undesirable corollary alterations in myocardial structure and function. These unfortunate precedents were based on high-level expression of constitutively activated AKT, predominantly in the cytoplasm of the cell. Based on subsequent studies establishing that activated AKT accumulates in the nucleus, we reasoned that the location of AKT, not simply the activity level, would be a critical determinant of the phenotypic outcome resulting from AKT activation. Using myocardial-specific expression of nuclear-targeted AKT (AKT/nuc), the proliferation of myocardial stem and progenitor cell populations is enhanced, casting new light on the implementation of AKT activity as a molecular interventional approach for treatment of cardiomyopathic damage resulting from acute injury, chronic stress, or the debilitating changes of aging.

"AKT"ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation. Publishing Authors By Initials

M Sussman,M Sussman,

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"AKT"ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Trends in cardiovascular medicine

VOLUME: 17

Page Numbers: 235-40

Journal Abbreviation: Trends Cardiovasc. Med.

ISSN: 1050-1738

DAY: 15

MONTH: Oct

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Biology, SDSU Heart Institute, San Diego State University, San Diego, CA 92182, USA. sussman@heart.sdsu.edu

Country: United States

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MEDLINETA: Trends Cardiovasc Med

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