"Accelerating aging" chemotherapy on aged animals: protective effect from nutraceutical modulation.

"Accelerating aging" chemotherapy on aged animals: protective effect from nutraceutical modulation. Research Abstract Details 

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"Accelerating aging" chemotherapy on aged animals: protective effect from nutraceutical modulation. Abstract Text:

ABSTRACT The aim of this study was to test a novel phytocompound in an experimental model of antitumor-induced immunosuppression. Five groups of mice were considered: young (Y) and aged (A) that were given intraperitoneally 10 doses of cyclophosphamide (CPX, 25mg/kg/bw) or CPX plus (150 mg/kg/bw) of the nutraceutical DTS (Denshichi-Tochiu-Sen), and control. After sacrifice, macrophage chemotaxis and serum levels of IFN-gamma, IL-2, and GM-CSF were determined. Liver and urinary bladder were examined histologically, as were the liver and kidney for redox enzymes. CPX significantly decreased macrophage chemotaxis and all cytokines (p < 0.05, A >> Y). DTS restored macrophage function and cytokine concentration (p < 0.001) and partly improved the necro-inflammatory score and substance P receptor expression in the bladder and the redox status in liver and kidney (p < 0.05). Such data suggest that DTS effectively prevents CPX-induced immune suppression and oxidative-inflammatory damage, which are particularly enhanced in aged organisms.

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"Accelerating aging" chemotherapy on aged animals: protective effect from nutraceutical modulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Rejuvenation research

VOLUME: 11

Page Numbers: 513-7

Journal Abbreviation: Rejuvenation Res

ISSN: 1549-1684

DAY: 29

MONTH: Apr

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 101213381

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AFFILIATION: WHO Center for Biotechnology and Traditional Medicine, University of Milano, Italy., GAIA Age-Management Foundation, Pavia, Italy.

Country: United States

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MEDLINETA: Rejuvenation Res

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