"Absolute" quantification in Magnetic Resonance Spectroscopy: validation of a clinical protocol in multiple sclerosis.

"Absolute" quantification in Magnetic Resonance Spectroscopy: validation of a clinical protocol in multiple sclerosis. Research Abstract Details 

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"Absolute" quantification in Magnetic Resonance Spectroscopy: validation of a clinical protocol in multiple sclerosis. Abstract Text:

Matthieu Bagory,Francoise Durand-Dubief,Danielle Ibarrola,Christian Confavreux,Dominique Sappey-Marinier,Matthieu Bagory, Durand-Dubief,Danielle Ibarrola,Christian Confavreux,Dominique Sappey-Marinier,

MRS allows to measure cerebral metabolites, thus helping to characterize brain disease diagnosis and followup. Metabolite concentration quantification is usually based on metabolite ratio referring to creatine. If this metabolite concentration is supposed to be constant, it may vary in pathological processes. Therefore, "absolute" concentration methodology is needed. The aim of this study is to validate a clinical "absolute" quantification protocol through the development of an external metabolic phantom, calibration and correction, and the investigation of reproducibility issues. When phantom stability was investigated by a short-term and a long-term reproducibility study, both Standard Deviations (SD) were in agreement with literature values. This "absolute" quantification method was applied to patients with Multiple Sclerosis (MS). The results show a significant decrease in both N-Acetyl Aspartate (NAA) and choline concentrations.

"Absolute" quantification in Magnetic Resonance Spectroscopy: validation of a clinical protocol in multiple sclerosis. Publishing Authors By Initials

M Bagory,F Durand-Dubief,D Ibarrola,C Confavreux,D Sappey-Marinier,M Bagory,F Durand-Dubief,D Ibarrola,C Confavreux,D Sappey-Marinier,

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"Absolute" quantification in Magnetic Resonance Spectroscopy: validation of a clinical protocol in multiple sclerosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 1

Page Numbers: 3458-61

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ISSN: 1557-170X

DAY: 16

MONTH: 11

YEAR: 2007

"Absolute" quantification in Magnetic Resonance Spectroscopy: validation of a clinical protocol in multiple sclerosis. Information

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LANGUAGE: eng

NlmUniqueID: 101243413

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AFFILIATION: CREATIS-LRMN, CNRS UMR 5220 & Inserm U630, Université de Lyon, 69621 Villeurbanne, France.

Country: United States

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