Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock.

Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock. Research Abstract Details 

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Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock. Abstract Text:

Natalia B Ivleva,Tiyu Gao,Andy C LiWang,Susan S Golden,

Circadian rhythms are endogenous cellular programs that time metabolic and behavioral events to occur at optimal times in the daily cycle. Light and dark cycles synchronize the endogenous clock with the external environment through a process called entrainment. Previously, we identified the bacteriophytochrome-like circadian input kinase CikA as a key factor for entraining the clock in the cyanobacterium Synechococcus elongatus PCC 7942. Here, we present evidence that CikA senses not light but rather the redox state of the plastoquinone pool, which, in photosynthetic organisms, varies as a function of the light environment. Furthermore, CikA associates with the Kai proteins of the circadian oscillator, and it influences the phosphorylation state of KaiC during resetting of circadian phase by a dark pulse. The abundance of CikA varies inversely with light intensity, and its stability decreases in the presence of the quinone analog 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone (DBMIB). The pseudo-receiver domain of CikA is crucial for sensitivity to DBMIB, and it binds the quinone directly, a demonstration of a previously unrecognized ligand-binding role for the receiver fold. Our results suggest that resetting the clock in S. elongatus is metabolism-dependent and that it is accomplished through the interaction of the circadian oscillator with CikA.

Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock. Publishing Authors By Initials

NB Ivleva,T Gao,AC LiWang,SS Golden,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 17468-73

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 6

MONTH: 11

YEAR: 2006

Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: metabolism

Chemical & Substance for Abstract: Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock. Information

Substance Name: CikA protein, bacteria

Registry Number: EC 2.7.3.-

Grant and Affiliation Information for Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock.

AFFILIATION: Center for Research on Biological Clocks, Department of Biology, Texas A&M University, College Station, TX 77843, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS39546

ACRONYM: NS

MEDLINETA: Proc Natl Acad Sci U S A

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