Quick-forming hydroxyapatite/agarose gel composites induce bone regeneration.

Quick-forming hydroxyapatite/agarose gel composites induce bone regeneration. Research Abstract Details 

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Quick-forming hydroxyapatite/agarose gel composites induce bone regeneration. Abstract Text:

Junji Watanabe,Masafumi Kashii,Makoto Hirao,Kunihiro Oka,Kazuomi Sugamoto,Hideki Yoshikawa,Mitsuru Akashi,Junji Watanabe,Masafumi Kashii,Makoto Hirao,Kunihiro Oka,Kazuomi Sugamoto,Hideki Yoshikawa,Mitsuru Akashi,

We investigated the fundamental properties of quick-forming hydroxyapatite (HAp)/agarose gel composites, and evaluated their potential as an injectable bone substitute. From scanning electron microscope observations, the HAp/agarose gel composites produced by an innovative electrophoretic process showed an interconnecting structure with the HAp particles. The diameter of the HAp particles was roughly 1 microm, and the total amount of HAp particles was estimated by a quantification of the calcium ions. In the case of 1 mg of dry composite, 10 microg of HAp was formed in the agarose gel. Moreover, X-ray diffraction analysis revealed that the HAp particles had an amorphous structure, so the HAp particles were expected to dissolve under physiological conditions relative to the HAp with higher crystallinity. The advantages of the resultant HAp/agarose gel composites are ease of handling, close contact with the surrounding tissues, and ease of use as an injectable material. As a preliminary animal study, the composites were implanted into the medial femoral condyle of rabbits. After implantation, the process of bone regeneration was evaluated by microfocus-computed tomography (microCT) and histological analysis. At 2 weeks postoperatively, newly-formed bone was observed at the edge of the bone defect site, and at 4 weeks postoperatively, excellent bone regeneration was observed. The implanted composite gradually degraded, and disappeared at 8 weeks postoperatively. This result indicated that the composite dissolved rapidly, and was replaced by newly-formed bone. Quick-forming HAp/agarose gel composites may be a good candidate as an injectable biomaterial, particularly in the fields of orthopedic, oral, and maxillofacial surgery.

Quick-forming hydroxyapatite/agarose gel composites induce bone regeneration. Publishing Authors By Initials

J Watanabe,M Kashii,M Hirao,K Oka,K Sugamoto,H Yoshikawa,M Akashi,J Watanabe,M Kashii,M Hirao,K Oka,K Sugamoto,H Yoshikawa,M Akashi,

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Quick-forming hydroxyapatite/agarose gel composites induce bone regeneration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomedical materials research. Part A

VOLUME: 83

Page Numbers: 845-52

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ISSN: 1549-3296

DAY: 1

MONTH: Dec

YEAR: 2007

Quick-forming hydroxyapatite/agarose gel composites induce bone regeneration. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Quick-forming hydroxyapatite/agarose gel composites induce bone regeneration.

AFFILIATION: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Country: United States

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MEDLINETA: J Biomed Mater Res A

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