Question 1: Peptide nucleic acids and the origin and homochirality of life.

Question 1: Peptide nucleic acids and the origin and homochirality of life. Research Abstract Details 

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Question 1: Peptide nucleic acids and the origin and homochirality of life. Abstract Text:

Peter E Nielsen,Peter E Nielsen,

The possibilities of pseudo peptide DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed. In particular a scenario is proposed in which protocells with an achiral genetic material through several generations stepwise is converted into a chiral genetic material, e.g., by incorporation of RNA units. Provided that a sufficiently large sequence space is occupied, a selection process based on catalytic function in which a single cell (first common ancestor) has a definite evolutionary advantage, selection of this cell would by contingency also lock it into homochirality.

Question 1: Peptide nucleic acids and the origin and homochirality of life. Publishing Authors By Initials

PE Nielsen,PE Nielsen,

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Question 1: Peptide nucleic acids and the origin and homochirality of life. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Origins of life and evolution of the biosphere : t

VOLUME: 37

Page Numbers: 323-8

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ISSN: 0169-6149

DAY: 17

MONTH: 07

YEAR: 2007

Question 1: Peptide nucleic acids and the origin and homochirality of life. Information

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LANGUAGE: eng

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AFFILIATION: Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute, Blegdamsvej 3c, DK-2200, Copenhagen N, Denmark. pen@imbg.ku.dk

Country: Netherlands

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MEDLINETA: Orig Life Evol Biosph

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