Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells.

Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells. Research Abstract Details 

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Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells. Abstract Text:

Ken-Tye Yong,Jun Qian,Indrajit Roy,Hoon Hi Lee,Earl J Bergey,Kenneth M Tramposch,Sailing He,Mark T Swihart,Anirban Maitra,Paras N Prasad,

Live cell imaging using CdSe/CdS/ZnS quantum rods (QRs) as targeted optical probes is reported. The QRs, synthesized in organic media using a binary surfactant mixture, were dispersed in aqueous media using mercaptoundecanoic acid (MUA) and lysine. Transferrin (Tf) was linked to the QRs to produce QR-Tf bioconjugates that were used for targeted in vitro delivery to a human cancer cell line. Confocal and two-photon imaging were used to confirm receptor-mediated uptake of QR-Tf conjugates into the HeLa cells, which overexpress the transferrin receptor (TfR). Uptake was not observed with QRs that lacked Tf functionalization or with cells that were presaturated with free Tf and then treated with Tf-functionalized QRs.

Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells. Publishing Authors By Initials

KT Yong,J Qian,I Roy,HH Lee,EJ Bergey,KM Tramposch,S He,MT Swihart,A Maitra,PN Prasad,

For similar proteins: blood proteins: acute-phase proteins: transferrin research abstracts see: proteins: blood proteins: acute-phase proteins: transferrin research

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Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nano letters

VOLUME: 7

Page Numbers: 761-5

Journal Abbreviation: Nano Lett.

ISSN: 1530-6984

DAY: 9

MONTH: 02

YEAR: 2007

Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 101088070

Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells. Keywords Mesh Terms:

KEYWORDS: Transferrin

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells. Information

Substance Name: Transferrin

Registry Number: 11096-37-0

Grant and Affiliation Information for Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells.

AFFILIATION: Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York, Buffalo, New York 14260-4200, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01CA119397

ACRONYM: CA

MEDLINETA: Nano Lett

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