Quantitative trait locus (QTL) mapping in aging systems.

Quantitative trait locus (QTL) mapping in aging systems. Research Abstract Details 

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Quantitative trait locus (QTL) mapping in aging systems. Abstract Text:

Hui-Chen Hsu,Lu Lu,Nengjun Yi,Gary Van Zant,Robert W Williams,John D Mountz,

Understanding the genetic basis of the effects of aging on the decline in the immune response is an enormous undertaking. The most prominent age-related change in the immune system is thymic involution. This chapter will focus on the use of C57BL/6 J X DBA/2 J (BXD) recombinant inbred (RI) strains of mice to map genetic loci associated with age-related thymic involution in mice. Strategies to improve the power and precision in which complex traits such as the age-related decline in the immune response have been applied to the large set of BXD RI strains to detect quantitative trait loci (QTLs) that underlie thymic involution. More importantly, approaches have been developed to enable higher resolution mapping of these QTLs and, in some cases, may be adequate to carry out direct identification of candidate genes. It is likely that, given the complexity of the immune system development, the number of cells involved in an immune response, and especially the changes in the immune system with aging, multiple genetic loci and genes will contribute to the age-related changes in the immune response. This chapter outlines ongoing and general quantitative genetic linkage strategies that can be used for mapping and identification of the quantitative trait loci that may have a significant impact on age-related alteration of the immune system.

Quantitative trait locus (QTL) mapping in aging systems. Publishing Authors By Initials

HC Hsu,L Lu,N Yi,G Van Zant,RW Williams,JD Mountz,

For similar genetic structures: genome: genome components: genes: quantitative trait loci research abstracts see: genetic structures: genome: genome components: genes: quantitative trait loci research

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Quantitative trait locus (QTL) mapping in aging systems. Journal Published:

PUBLICATION TYPE: Review

Journal: Methods in molecular biology (Clifton, N.J.)

VOLUME: 371

Page Numbers: 321-48

Journal Abbreviation: Methods Mol. Biol.

ISSN: 1064-3745

DAY: 3

MONTH: 12

YEAR: 2007

Quantitative trait locus (QTL) mapping in aging systems. Information

Number of References: 58

LANGUAGE: eng

NlmUniqueID: 9214969

Quantitative trait locus (QTL) mapping in aging systems. Keywords Mesh Terms:

KEYWORDS: Quantitative Trait Loci

MESH TERMS: immunology

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Grant and Affiliation Information for Quantitative trait locus (QTL) mapping in aging systems.

AFFILIATION: Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.

Country: United States

AGENCY: United States NIAAA

GRANT: U24AA13513

ACRONYM: AA

MEDLINETA: Methods Mol Biol

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