Quantitative studies of gastric endocrine cells in patients receiving long-term treatment with omeprazole.

Quantitative studies of gastric endocrine cells in patients receiving long-term treatment with omeprazole. Research Abstract Details 

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Quantitative studies of gastric endocrine cells in patients receiving long-term treatment with omeprazole. Abstract Text:

W Creutzfeldt,R Lamberts,F Stöckmann,G Brunner,

A total of 36 patients with chronic gastric or oesophageal peptic ulceration (including 6 with antrectomy), resistant to high-dose ranitidine treatment for at least 3 months, were successfully treated with omeprazole 20-60 mg/day, for periods up to 3 years. Fasting serum gastrin levels were monitored at regular intervals during therapy and multiple gastric mucosal biopsies were taken during gastroscopy every 3-6 months. Gastrin levels increased significantly during the first 6 months of therapy from a mean of 81.5 to 206 pg/ml; a slight decrease was observed thereafter. There was no significant increase in the volume density of argyrophilic cells in the oxyntic mucosa. No clusters of endocrine cells were found in the oxyntic mucosa and no change of G-cell volume density occurred in the antral mucosa under therapy. Omeprazole therapy did not result in any changes in gastrin levels or oxyntic argyrophilic cells in the antrectomized patients. It is concluded that the moderate hypergastrinaemia observed during long-term omeprazole treatment in man does not induce hyperplasia of argyrophilic cells in the oxyntic mucosa.

Quantitative studies of gastric endocrine cells in patients receiving long-term treatment with omeprazole. Publishing Authors By Initials

W Creutzfeldt,R Lamberts,F Stöckmann,G Brunner,

For similar stomach ulcer research abstracts see: stomach ulcer research

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Quantitative studies of gastric endocrine cells in patients receiving long-term treatment with omeprazole. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 166

Page Numbers: 122-8; discussion 138-9

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1989

Quantitative studies of gastric endocrine cells in patients receiving long-term treatment with omeprazole. Information

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LANGUAGE: eng

NlmUniqueID: 437034

Quantitative studies of gastric endocrine cells in patients receiving long-term treatment with omeprazole. Keywords Mesh Terms:

KEYWORDS: Stomach Ulcer

MESH TERMS: pathology

Chemical & Substance for Abstract: Quantitative studies of gastric endocrine cells in patients receiving long-term treatment with omeprazole. Information

Substance Name: Omeprazole

Registry Number: 73590-58-6

Grant and Affiliation Information for Quantitative studies of gastric endocrine cells in patients receiving long-term treatment with omeprazole.

AFFILIATION: Dept. of Medicine, University of Göttingen, West Germany.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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