Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy.

Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy. Research Abstract Details 

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Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy. Abstract Text:

Sarah J Lincoln,Owen A Ross,Nicole M Milkovic,Dennis W Dickson,Alex Rajput,Christopher A Robinson,Spiridon Papapetropoulos,Deborah C Mash,Matthew J Farrer,Sarah J Lincoln,Owen A Ross,Nicole M Milkovic,Dennis W Dickson,Alex Rajput,Christopher A Robinson,Spiridon Papapetropoulos,Deborah C Mash,Matthew J Farrer,

Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the alpha-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.

Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy. Publishing Authors By Initials

SJ Lincoln,OA Ross,NM Milkovic,DW Dickson,A Rajput,CA Robinson,S Papapetropoulos,DC Mash,MJ Farrer,SJ Lincoln,OA Ross,NM Milkovic,DW Dickson,A Rajput,CA Robinson,S Papapetropoulos,DC Mash,MJ Farrer,

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Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Parkinsonism & related disorders

VOLUME: 13

Page Numbers: 340-2

Journal Abbreviation: Parkinsonism Relat. Disord.

ISSN: 1353-8020

DAY: 8

MONTH: 02

YEAR: 2007

Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy. Information

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LANGUAGE: eng

NlmUniqueID: 9513583

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Grant and Affiliation Information for Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy.

AFFILIATION: Department of Neuroscience, Molecular Genetics Laboratory and Core, Morris K. Udall Parkinson's Disease Research Center of Excellence, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Country: England

AGENCY: United States NINDS

GRANT: P50 NS 40256

ACRONYM: NS

MEDLINETA: Parkinsonism Relat Disord

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