Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy.

Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. Research Abstract Details 

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Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. Abstract Text:

Tim A J Hopper,Felix W Wehrli,Punam K Saha,Jalal B Andre,Alexander C Wright,Cheryl P Sanchez,Mary B Leonard,

OBJECTIVE: To determine the effects of renal osteodystrophy (ROD) on bone microarchitecture in growing rats. METHODS: A total of 24 rats underwent 5/6 nephrectomy (NX) and were fed a high-phosphorus diet to induce ROD; another 6 underwent sham NX. In vitro microcomputed tomography images (GEMS, London, Ontario, Canada) were obtained in the femoral metaphysis and midshaft. RESULTS: Trabecular and cortical bone volume/total volume (BV/TV) were significantly lower in NX specimens because of pores within the trabeculae and along the endosteal surface. Topological analysis using component labeling in 3-dimensions verified that trabecular pores connected to the marrow space. After the trabecular pores were filled using a morphological filter, trabecular thickness was significantly increased in NX. In contrast, cortical thickness was significantly decreased in NX compared with controls; however, after filling the endocortical pores, thickness did not differ. CONCLUSIONS: The ROD resulted in decreased cortical and trabecular BV/TV, increased porosity, and increased trabecular thickness. Advanced image processing algorithms demonstrated the effects of cortical and trabecular porosity on BV/TV and structure in ROD.

Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. Publishing Authors By Initials

TA Hopper,FW Wehrli,PK Saha,JB Andre,AC Wright,CP Sanchez,MB Leonard,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of computer assisted tomography

VOLUME: 31

Page Numbers: 320-8

Journal Abbreviation:

ISSN: 0363-8715

DAY: 3

MONTH: 12

YEAR: 2007

Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7703942

Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: methods

Chemical & Substance for Abstract: Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy.

AFFILIATION: School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, Australia.

Country: United States

AGENCY: United States NIDDK

GRANT: K08-DK02503

ACRONYM: DK

MEDLINETA: J Comput Assist Tomogr

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