Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Research Abstract Details 

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Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Abstract Text:

DAF-2, an insulin receptor-like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin.

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Publishing Authors By Initials

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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MEDLINE DATE:

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Science (New York, N.Y.)

VOLUME: 317

Page Numbers: 660-3

Journal Abbreviation: Science

ISSN: 1095-9203

DAY: 3

MONTH: Aug

YEAR: 2007

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 404511

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Information

Substance Name: Calcineurin

Registry Number: EC 3.1.3.-

Grant and Affiliation Information for Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.

AFFILIATION: Scripps Research Institute, La Jolla, CA92037, USA.

Country: United States

AGENCY: United States NCRR

GRANT: P41 RR11823-10

ACRONYM: RR

MEDLINETA: Science

REFSOURCE: Science. 2007 Aug 3;317(5838):603-4

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