Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates.

Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates. Research Abstract Details 

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Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates. Abstract Text:

C W Hendrix,E J Fuchs,K J Macura,L A Lee,T L Parsons,R P Bakshi,W A Khan,A Guidos,J P Leal,R Wahl,C W Hendrix,E J Fuchs,K J Macura,L A Lee,T L Parsons,R P Bakshi,W A Khan,A Guidos,J P Leal,R Wahl,C W Hendrix,E J Fuchs,K J Macura,L A Lee,T L Parsons,R P Bakshi,W A Khan,A Guidos,J P Leal,R Wahl,

Understanding the distribution of microbicide and human immunodeficiency virus (HIV) within the gastrointestinal tract is critical to development of rectal HIV microbicides. A hydroxyethylcellulose-based microbicide surrogate or viscosity-matched semen surrogate, labeled with gadolinium-DTPA (diethylene triamine pentaacetic acid) and (99m)Technetium-sulfur colloid, was administered to three subjects under varying experimental conditions to evaluate effects of enema, coital simulation, and microbicide or semen simulant over 5 h duration. Quantitative assessment used single photon emission computed tomography (SPECT)/computed tomography (CT) and magnetic resonance imaging (MRI) imaging, and sigmoidoscopic sampling. Over 4 h, radiolabel migrated cephalad in all studies by a median (interquartile range) of 50% (29-102%; P<0.001), as far as the splenic flexure ( approximately 60 cm) in 12% of studies. There was a correlation in concentration profile between endoscopic sampling and SPECT assessments. HIV-sized particles migrate retrograde, 60 cm in some studies, 4 h after simulated ejaculation in our model. SPECT/CT, MRI, and endoscopy can be used quantitatively to facilitate rational development of microbicides for rectal use.Clinical Pharmacology & Therapeutics (2008) 83, 97-105; doi:10.1038/sj.clpt.6100236; published online 16 May 2007.

Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates. Publishing Authors By Initials

CW Hendrix,EJ Fuchs,KJ Macura,LA Lee,TL Parsons,RP Bakshi,WA Khan,A Guidos,JP Leal,R Wahl,CW Hendrix,EJ Fuchs,KJ Macura,LA Lee,TL Parsons,RP Bakshi,WA Khan,A Guidos,JP Leal,R Wahl,CW Hendrix,EJ Fuchs,KJ Macura,LA Lee,TL Parsons,RP Bakshi,WA Khan,A Guidos,JP Leal,R Wahl,

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Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical pharmacology and therapeutics

VOLUME: 83

Page Numbers: 97-105

Journal Abbreviation: Clin. Pharmacol. Ther.

ISSN: 1532-6535

DAY: 16

MONTH: 05

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 372741

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AFFILIATION: 1Department of Medicine, Division of Clinical Pharmacology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Country: United States

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MEDLINETA: Clin Pharmacol Ther

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