Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes.

Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes. Abstract Text:

Javier Vela,Jordi Cirera,Jeremy M Smith,Rene J Lachicotte,Christine J Flaschenriem,Santiago Alvarez,Patrick L Holland,

Six of the seven iron atoms in the iron-molybdenum cofactor of nitrogenase display an unusual geometry, which is distorted from the tetrahedral geometry that is most common in iron-sulfur clusters. This distortion pulls the iron along one C3 axis of the tetrahedron toward a trigonal pyramid. The trigonal pyramidal coordination geometry is rare in four-coordinate transition metal complexes. In order to document this geometry in a systematic fashion in iron(II) chemistry, we have synthesized a range of four-coordinate iron(II) complexes that vary from tetrahedral to trigonal pyramidal. Continuous shape measures are used for a quantitative comparison of the stereochemistry of the Fe atoms in the iron-molybdenum cofactor with those of the presently and previously reported model complexes, as well as with those in polynuclear iron-sulfur compounds. This understanding of the iron coordination geometry is expected to assist in the design of synthetic analogues for intermediates in the nitrogenase catalytic cycle.

Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes. Publishing Authors By Initials

J Vela,J Cirera,JM Smith,RJ Lachicotte,CJ Flaschenriem,S Alvarez,PL Holland,

For similar enzymes and coenzymes: enzymes: oxidoreductases: nitrogenase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: nitrogenase research

PUBMED ID PMID:

MEDLINE DATE:

Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Inorganic chemistry

VOLUME: 46

Page Numbers: 60-71

Journal Abbreviation:

ISSN: 0020-1669

DAY: 8

MONTH: Jan

YEAR: 2007

Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 366543

Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes. Keywords Mesh Terms:

KEYWORDS: Nitrogenase

MESH TERMS: chemistry

Chemical & Substance for Abstract: Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes. Information

Substance Name: Nitrogenase

Registry Number: EC 1.18.6.1

Grant and Affiliation Information for Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes.

AFFILIATION: Department of Chemistry, University of Rochester, Rochester, New York 14627, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM-65313

ACRONYM: GM

MEDLINETA: Inorg Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic ironII model complexes Related Publications

• 2-Methoxycanthin-6-one: A New Alkaloid from the Stem Wood of Quassia amara.
• A dinucleating ligand related to the beta-diketiminates.
• Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency.
• AmphiBMP2/4, an amphioxus bone morphogenetic protein closely related to Drosophila decapentaplegic and vertebrate BMP2 and BMP4: insights into evolution of dorsoventral axis specification.
• Attitudes to the use of prophylaxis for thrombo-embolism in neurosurgical patients.
• Binding affinity of alkynes and alkenes to low-coordinate iron.
• Cap gun burns in children.
• Characterization of anisotropic myocardial backscatter using spectral slope, intercept and midband fit parameters.
• Cis-regulation of the amphioxus engrailed gene: insights into evolution of a muscle-specific enhancer.
• Cytokines and other immunological biomarkers in children's environmental health studies.
• Dissociable effects of disconnecting amygdala central nucleus from the ventral tegmental area or substantia nigra on learned orienting and incentive motivation.
• Expression of Th1/Th2 cytokines in human blood after in vitro treatment with chlorpyrifos, and its metabolites, in combination with endotoxin LPS and allergen Der p1.
• Fulminant mulch pneumonitis: an emergency presentation of chronic granulomatous disease.
• Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation.
• Global and local development of gray and white matter volume in normal children and adolescents.
• Insertion of a MalE beta-galactosidase fusion protein into the envelope of Escherichia coli disrupts biogenesis of outer membrane proteins and processing of inner membrane proteins.
• Learned contextual cue potentiates eating in rats.
• Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma.
• Mechanistic insight into N=N cleavage by a low-coordinate iron(II) hydride complex.
• Mouse models of brain tumors and their applications in preclinical trials.
• Notch signaling enhances nestin expression in gliomas.
• Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment.
• Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes.
• Rapid viral quasispecies evolution: implications for vaccine and drug strategies.
• Reinforcer-specificity of appetitive and consummatory behavior of rats after Pavlovian conditioning with food reinforcers.
• Sex differences in the development of neuroanatomical functional connectivity underlying intelligence found using Bayesian connectivity analysis.
• Sinking velocities of phytoplankton measured on a stable density gradient by laser scanning.
• Survey of Connecticut Nurse-Midwives.
• Testicular nubbins and prosthesis insertion: is it all just in the timing?
• Winter travel assignments appeal to RN, ski bum.