Quantitative evaluation of the effect of propylene glycol on BBB permeability.

Quantitative evaluation of the effect of propylene glycol on BBB permeability. Research Abstract Details 

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Quantitative evaluation of the effect of propylene glycol on BBB permeability. Abstract Text:

Rohit Sood,Saeid Taheri,Eduardo Y Estrada,Gary A Rosenberg,

PURPOSE: To establish the blood-brain barrier (BBB) blocking property of propylene glycol (PG) using the (14)C sucrose technique, quantitatively evaluate the effect of PG on BBB permeability using an MRI technique based on graphical analysis, and demonstrate the sensitivity of MRI for testing newer investigational drugs. MATERIALS AND METHODS: Brain uptake of sucrose was measured in treated (PG+) and untreated (PG-) rats using a (14)C sucrose technique in rat brains (N = 10) that had undergone two hours of middle cerebral artery occlusion (MCAO) and three hours of reperfusion. Another group of PG+ and PG- rats (N = 8) underwent MRI. T2-weighted (T2W) and diffusion-weighted (DW) images were acquired on a 4.7T MR system. A rapid T1 mapping protocol was implemented to acquire a baseline data set followed by postinjection data sets at regular intervals. The data were postprocessed pixelwise to generate permeability coefficient color maps. RESULTS: A significant (P < 0.05) reduction in (14)C sucrose space was observed on the ischemic side of PG+ rats only. Permeability coefficient estimates obtained by MRI from the ipsilateral hemisphere in PG+ rats were significantly lower than those in PG- rats (P < 0.05). There was no significant change on the contralateral side in PG+ rats. The results show that PG protects the BBB in ischemic stroke, and MRI measurements are sufficiently sensitive to noninvasively detect small drug effects. CONCLUSION: MRI is useful for evaluating the BBB blocking effect of PG in an ischemic stroke model of rat brain. The results from the MR experiment agree well with findings from the (14)C sucrose technique.

Quantitative evaluation of the effect of propylene glycol on BBB permeability. Publishing Authors By Initials

R Sood,S Taheri,EY Estrada,GA Rosenberg,

For similar carbohydrates: polysaccharides: oligosaccharides: disaccharides: sucrose research abstracts see: carbohydrates: polysaccharides: oligosaccharides: disaccharides: sucrose research

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Quantitative evaluation of the effect of propylene glycol on BBB permeability. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of magnetic resonance imaging : JMRI

VOLUME: 25

Page Numbers: 39-47

Journal Abbreviation:

ISSN: 1053-1807

DAY: 3

MONTH: Jan

YEAR: 2007

Quantitative evaluation of the effect of propylene glycol on BBB permeability. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9105850

Quantitative evaluation of the effect of propylene glycol on BBB permeability. Keywords Mesh Terms:

KEYWORDS: Sucrose

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Quantitative evaluation of the effect of propylene glycol on BBB permeability. Information

Substance Name: Gadolinium DTPA

Registry Number: 80529-93-7

Grant and Affiliation Information for Quantitative evaluation of the effect of propylene glycol on BBB permeability.

AFFILIATION: Department of Neurology, University of New Mexico, Albuquerque, New Mexico, USA. rsood@salud.unm.edu

Country: United States

AGENCY: United States NINDS

GRANT: R01NS045847

ACRONYM: NS

MEDLINETA: J Magn Reson Imaging

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