Quantitative comparison of the relative cell permeability of cyclic and linear peptides.

Quantitative comparison of the relative cell permeability of cyclic and linear peptides. Research Abstract Details 

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Quantitative comparison of the relative cell permeability of cyclic and linear peptides. Abstract Text:

Yong-Uk Kwon,Thomas Kodadek,

Cyclic peptides are of considerable interest as potential protein ligands. It has been postulated that cyclic molecules might be more cell permeable than their linear counterparts due to their reduced conformational flexibility. We report a study that tests this hypothesis by using a quantitative, reporter gene-based assay that measures the relative cell permeability of steroid conjugates of molecules of interest. We demonstrate that cyclic peptides are, in fact, not generally more permeable than their linear counterparts.

Quantitative comparison of the relative cell permeability of cyclic and linear peptides. Publishing Authors By Initials

YU Kwon,T Kodadek,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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MEDLINE DATE:

Quantitative comparison of the relative cell permeability of cyclic and linear peptides. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Chemistry & biology

VOLUME: 14

Page Numbers: 671-7

Journal Abbreviation: Chem. Biol.

ISSN: 1074-5521

DAY: 3

MONTH: Jun

YEAR: 2007

Quantitative comparison of the relative cell permeability of cyclic and linear peptides. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9500160

Quantitative comparison of the relative cell permeability of cyclic and linear peptides. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: metabolism

Chemical & Substance for Abstract: Quantitative comparison of the relative cell permeability of cyclic and linear peptides. Information

Substance Name: Luciferases

Registry Number: EC 1.13.12.-

Grant and Affiliation Information for Quantitative comparison of the relative cell permeability of cyclic and linear peptides.

AFFILIATION: Division of Translational Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

Country: England

AGENCY: United States NHLBI

GRANT: N01-HV-28185

ACRONYM: HV

MEDLINETA: Chem Biol

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