Quantifying the risk from ovine BSE and the impact of control strategies.

Quantifying the risk from ovine BSE and the impact of control strategies. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Quantifying the risk from ovine BSE and the impact of control strategies. Abstract Text:

Helen R Fryer,Matthew Baylis,Kumar Sivam,Angela R McLean,Helen R Fryer,Matthew Baylis,Kumar Sivam,Angela R McLean,

Although no naturally infected sheep with bovine spongiform encephalopathy (BSE) has ever been discovered, it remains possible that BSE once infected the UK sheep population, has been transmitted between sheep, and is still present today. We constructed a mathematical model to assess the current maximum theoretical exposure to consumers from BSE-infected ovine material and to estimate the risk reduction that could be achieved by abattoir-based control options if BSE-infected sheep were ever found in the national flock. We predict that, if present, the exposure to consumers from a single BSE-infected sheep would be high: one sheep, close to the end of its incubation period, is likely to contribute 10-1000 times more infectious material than a fully infectious cow. Furthermore, 30% of this exposure comes from infectivity residing in lymphatic and peripheral tissue that cannot be completely removed from a carcass.We are 95% confident that throughout Great Britain, no more than four sheep flocks currently harbour an ongoing BSE epidemic. However, since the exposure from a single infected sheep is high, the annual human exposure from four 'typical' BSE-infected flocks could be considerable. Small reductions in exposure could be achieved by strategies based on tissue testing, a 12-month age restriction or expanded definitions of high-risk tissues. A six-month age restriction is likely to be more effective and genotype-based strategies the most effective.

Quantifying the risk from ovine BSE and the impact of control strategies. Publishing Authors By Initials

HR Fryer,M Baylis,K Sivam,AR McLean,HR Fryer,M Baylis,K Sivam,AR McLean,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Quantifying the risk from ovine BSE and the impact of control strategies. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings. Biological sciences / The Royal Socie

VOLUME: 274

Page Numbers: 1497-503

Journal Abbreviation:

ISSN: 0962-8452

DAY: 22

MONTH: Jun

YEAR: 2007

Quantifying the risk from ovine BSE and the impact of control strategies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101245157

Quantifying the risk from ovine BSE and the impact of control strategies. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Quantifying the risk from ovine BSE and the impact of control strategies. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Quantifying the risk from ovine BSE and the impact of control strategies.

AFFILIATION: Institute for Emergent Infections of Humans, James Martin 21st Century School, Department of Zoology, Oxford University, South Parks Road, Oxford OX1 3PS, UK. helen.fryer@zoo.ox.ac.uk

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Proc Biol Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Quantifying the risk from ovine BSE and the impact of control strategies Related Publications

• Activation of the SCPx promoter in mouse adrenocortical Y1 cells.
• Analysis of the incidence and risk factors for wound infections in open bariatric surgery.
• Asthma patient education opportunities in predominantly minority urban communities.
• Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits.
• Diversity of risk factors for stroke: the putative roles and mechanisms of depression and air pollution.
• Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.
• Efficacy of an inhibitor of adhesion molecule expression (GI270384X) in the treatment of experimental colitis.
• Estimated and measured blood alcohol levels in the night-time driving population.
• Ethics & AIDS in Africa: the challenge to our thinking--edited by Anton A. van Niekerk and Loretta M. Kopelman.
• Ethnic differences in physical activity prevalence in new zealand: 760: may 31 3:30 PM - 3:45 PM.
• Filaggrin mutations are genetic modifying factors exacerbating X-linked ichthyosis.
• Files that never grow old.
• Gliosarcoma with osteosarcomatous differentiation: review of radiological and pathological features.
• Improving respiration in patients with tetraplegia by functional electrical stimulation: an anatomical perspective.
• In this issue of Current Oncology.
• In this issue of Current Oncology.
• In this issue of Current Oncology.
• Introduction of an isolation policy in paediatric wards.
• Marion's message. The safest kind of breech.
• Numerical reproduction in pigeons.
• Pre- and post-prandial plasma ghrelin levels do not correlate with satiety or failure to achieve a successful outcome after Roux-en-Y gastric bypass.
• Predictive value of N-terminal pro-brain natriuretic peptide in sepsis.
• Prostaglandin F2alpha suppresses rat steroidogenic acute regulatory protein expression via induction of Yin Yang 1 protein and recruitment of histone deacetylase 1 protein.
• Quantifying the risk from ovine BSE and the impact of control strategies.
• Regulation of alternative splicing of liver scavenger receptor class B gene by estrogen and the involved regulatory splicing factors.
• Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.
• Spatial scale of the patchiness of plant poisons: a critical influence on foraging efficiency.
• The effect of random breath testing on perception of likelihood of apprehension and on illegal drink-driving.
• The immune response to coitus and conception.
• What and who are clinical ethics committees for?