Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness.

Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness. Research Abstract Details 

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Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness. Abstract Text:

Elan D Louis,Wei Zheng,Wendy Jiang,Kenneth T Bogen,Garrett A Keating,

Harmane, one of the heterocyclic amines (HCAs), is a potent neurotoxin linked to human diseases. Dietary exposure, especially in cooked meats, is the major source of exogenous exposure for humans. However, knowledge of harmane concentrations in cooked meat samples is limited. Our goals were to (1) quantify the concentration of harmane in different types of cooked meat samples, (2) compare its concentration to that of other more well-understood HCAs, and (3) examine the relationship between harmane concentration and level of doneness. Thirty barbecued/grilled meat samples (8 beef steak, 12 hamburger, 10 chicken) were analyzed for harmane and four other HCAs (2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine [PhIP], amino-3,8-dimethylimidazo[4,5-f]quinoxaline [MeIQx], 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline [DiMeIQx], and 2-amino-1,6-dimethylfuro[3,2-e]imidazo[4,5-b]pyridine [IFP]). Mean (+/- SD) harmane concentration was 5.63 (+/- 6.63) ng/g; harmane concentration was highest in chicken (8.48 +/- 9.86 ng/g) and lowest in beef steak (3.80 +/- 3.6 ng/g). Harmane concentration was higher than that of the other HCAs and significantly correlated with PhIP concentration. Harmane concentration was associated with meat doneness in samples of cooked beef steak and hamburger, although the correlation between meat doneness and concentration was greater for PhIP than for harmane. Evidence indicates that harmane was detectable in nanograms per gram quantities in cooked meat (especially chicken) and, moreover, was more abundant than other HCAs. There was some correlation between meat doneness and harmane concentration, although this correlation was less robust than that observed for PhIP. Data such as these may be used to improve estimation of human dietary exposure to this neurotoxin.

Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness. Publishing Authors By Initials

ED Louis,W Zheng,W Jiang,KT Bogen,GA Keating,

For similar chemical actions and uses: toxic actions: noxae: neurotoxins research abstracts see: chemical actions and uses: toxic actions: noxae: neurotoxins research

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Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of toxicology and environmental health. Pa

VOLUME: 70

Page Numbers: 1014-9

Journal Abbreviation: J. Toxicol. Environ. Health Pa

ISSN: 1528-7394

DAY: 3

MONTH: Jun

YEAR: 2007

Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100960995

Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness. Keywords Mesh Terms:

KEYWORDS: Neurotoxins

MESH TERMS: analysis

Chemical & Substance for Abstract: Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness. Information

Substance Name: harman

Registry Number: 486-84-0

Grant and Affiliation Information for Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness.

AFFILIATION: Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA.

Country: England

AGENCY: United States NINDS

GRANT: R01 NS39422

ACRONYM: NS

MEDLINETA: J Toxicol Environ Health A

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